Sumitomo Chemical Company, Limited

Daiichi Pharmaceutical Co., Ltd.

Ryuhei Wakita

Nobushige Itaya

Hiroyuki Asako

Kenji Matsumura

Mikio Sasaki

Nobuya Itoh

Masatoshi Shimizu

Yusuke Yukimoto

Eiji Yamauchi

Takashi Namba

Asako Kubo

A process for producing a purified O-(2,6-dichloro-4-methylphenyl)-O,O-dimethyl phosphorothioate, the process comprising:

Process for production of purified O-(2,6-dichloro-4-methyl-phenyl) O,O-dimethyl phosphorothioate

There are provided a polynucleotide sequence coding for an amino acid sequence capable of preferentially producing (S)-4-bromo-3-hydroxy-butanoate by asymmetrically reducing 4-bromo-3-oxobutanoate, A DNA construct having a promoter in operative linkage with the polynucleotide sequence, a recombinant vector containing the polynucleotide sequence, a transformant, a recombinant vector and the like.

Process for producing optically active 4-halo-3-hydroxybutanoate

There are provided a method for producing a 4-cyano-3-oxobutanoate by reacting a 4-halo-3-oxobutanoate with an alkaline metal cyanide in methanol, a process for producing 4-cyano-3-hydroxybutanoate therefrom.

Method for producing 4-cyano-3-oxobutanoate and 4-ctano-3-hydroxybutanoate

A process for producing a 2-fluorocyclopropane-carboxylic acid of formula �I! ##STR1## by reducing a 2-halo-2-fluorocyclopropanecarboxylic acid of formula �II! ##STR2## the reduction being carried out by developing a Raney nickel alloy in the presence of the 2-halo-2-fluorocyclo-propanecarboxylic acid of formula �II!, or by contacting the 2-halo-2-fluorocyclopropanecarboxylic acid of formula �II! with hydrogen in an aqueous solvent using a Raney nickel catalyst.

Process for producing 2-fluorocyclopropancecarboxlic acid

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Toyonaka, Japan

Ryuhei Wakita