Sumitomo Pharmaceuticals Company Limited

Dainippon Sumitomo Pharma Co., Ltd.

Sumitomo Manufacturing Company Limited

Ryu Nagata

Norihiko Tanno

Tohru Tatsuno

Nobuyuki Ae

Tatsuya Fujibayashi

Teruhisa Tokunaga

Kazuhito Ikeda

Hiroki Ogo

Kantaro Ushiroda

Toshio Nishihara

Kozo Yoshida

Toru Kodo

Katsunori Maruta

Makoto Kitoh

Hiroshi Yamaguchi

Yoko Takahashi

Shuji Masumoto

Kazuo Kumagai

Yasuyuki Ueki

Hisakazu Kishimoto

Takashi Umezome

Kazuhiko Okazaki

Ken-ichi Watanabe

William Ewan Hume

W Ewan Hume

Kiyotaka Iwai

Seiji Katayama

Tsuyoshi Takasaki

Disclosed is a compound represented by the formula (1) below, a prodrug thereof or a pharmaceutically acceptable salt of either, which is useful as a therapeutic, preventive or ameliorating agent for diabetes and the like. (In the formula, Rrepresents an optionally substituted carbamoyl group or the like; X represents a hydroxyl group or the like; Wand Windependently represent a single bond or methylene; Rand Rindependently represent a hydrogen atom, an optionally substituted alkyl group or the like; and Ar represents an optionally substituted aryl group or the like.)

Oxindole derivative as feeding control agent

A compound of the following formula (1), or its prodrug or pharmaceutically acceptable salt thereof, being useful as a diabetic medicine or preventive, or blood sugar regulator, or therapeutic agent for hyperlipemia, etc.  wherein the ring Z is an optionally substituted heteroaryl, Wis a single bond, lower alkylene, etc., Aris an optionally substituted aryl, etc., Wis a single bond, lower alkylene, etc., Aris an optionally substituted arylene, etc., each of Wand Wis an optionally substituted lower alkylene, etc., and Ris carboxyl, an alkoxycarbonyl.

Heteroaryl derivatives

A heteroaryl derivative of the formula (1): (wherein Ring Z is an optionally substituted heteroaryl, Ris a carboxyl group or an alkoxycarbonyl group, etc., Wand Ware an optionally substituted lower alkylene, Aris an optionally substituted arylene or an optionally substituted heteroarylene, Wis a single bond, a lower alkylene, a lower alkenylene, etc., Wis a single bond, &#x2014;NR&#x2014;, etc., Aris an optionally substituted aryl or an optionally substituted heteroaryl), or a prodrug thereof, or a pharmaceutically acceptable salt thereof.

Heteroaryl derivative

A novel pyrrole derivative represented by the following formula (1) and a salt thereof: wherein Rmeans substituted alkenyl, etc.; Rmeans substituted benzoyl, etc.; and Rto Reach means hydrogen, alkyl, halogeno, etc. The derivative and salt have antidiabetic activity.

Pyrrole derivative

A compound of the formula:wherein Ar is optionally substituted phenyl, etc.; n is 0, 1 or 2;

Amide derivative

Pyrrole derivatives

Oxindole derivative

The present invention provides novel tricyclic indole-2-carboxylic acids of the following chemical formula, which have potent NMDA receptor antagonistic activity.

Tricyclic indole-2-carboxylic acid compound used as NMDA receptor antagonist

A compound represented by the figure (1) or a pharmaceutically acceptable salt thereof is useful as medicament for treating retinal degenerative disorders:

Nitrone derivatives

A tricyclic quinoxalinedione derivative represented by the formula 1: ##STR1## wherein X represents hydrogen, alkyl, halogen, cyano, trifluoromethyl, or nitro;

Tricyclic quinoxalinedione derivatives

Tricyclic quinoxalinediones

A tricyclic indole-2-carboxylic acid derivative represented by the formula 1: ##STR1## wherein X represents alkyl, halogen or cyano;

Tricyclic indole-2-carboxylic acid derivatives

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Nishinomiya, Japan

Ryu Nagata