Hitachi, Ltd.

Hitachi-high-technologies Corporation

Amgen Inc.

Teijin Pharma Limited

Ryota Nakajima

Takayuki Nozaki

Guangbin Zhou

Shizu Matsuoka

Masaharu Kiyama

Masakazu Sugaya

Koichi Terada

Taku Nakamura

Toyoshige Kobayashi

Shizu Takeda

Naoko Senda

Daisuke Suzuki

Patricia Lopez

Shon Booker

Kazumichi Imai

Ryan D White

Victor J Cee

Hiroaki Nakagawa

Timothy David Cushing

Xiaolin Hao

Ryan Paul Wurz

Brian M Fox

Youngsook Shin

Hilary Plake Beck

Lewis D Pennington

Steven H Olson

Yoko Inoue

Stephanie Geuns-Meyer

Taizo Miyazaki

Jason Brooks Human

Zihao Hua

Xiao Mei Zheng

Oleg Epstein

Nagasree Chakka

Akihiro Shimase

Kenichi Minami

Howard Bregman

Kosuke Sasaki

Keiko Shimada

Kazuhisa Okada

Kenta Hibiya

Shuyan Yi

Hiroyuki Oono

Yumiko Igarashi

Jun Hirata

Shinji Kakuda

Shon Keith Booker

Jason Human

Nozaki Takayuki

The purpose of the present invention is to provide a valve mechanism which features a simple structure adapted to collectively control the supply of gas or culture medium to a plurality of cultivation containers for simultaneous cultivation and to enhance the reliability of the valve mechanism. The valve mechanism of the invention is a valve mechanism for opening and closing passages for liquid or gas. The valve mechanism includes: clip members adapted to close a plurality of tube passages, respectively; a multiple cam member for opening the clip members in sequence by making contact with the clip members; and a rotational mechanism for rotating the multiple cam member. The clip member includes: a spring for closing a clip thereof; and a clip contact portion for a cam contact portion of the multiple cam member to make contact therewith.

Valve mechanism, cell cultivation apparatus using same, and cell cultivation method

There is the problem that a liquid culture medium fed by a pump has a high frequency of contact with a gas during movement in a tube, and the pH value of the liquid culture medium before and after feeding changes easily. In a liquid feeder and a cell culture apparatus provided therewith, a feed pipeis connected with a gas bag, the liquid to be fed into the feed pipeis fed so as to be sandwiched by a gas for suppressing the qualitative changes of the liquid. Furthermore, the gas bag is connected with a containerfor holding a liquid, and holds the gas for suppressing qualitative changes of the liquid in a gas phase of the container.

Liquid feeding device and cell culture device

An automatic culture device which employs closed-system culture vessels and in which, when a passage part () and a rotational valve mechanism () are configured, the multiple culture vessels in a culture vessel part () can be rendered equal in liquid-feeding conditions by, for example, regulating the length of each passage. As a result, the evenness in quality of cells incubated in the multiple culture vessels is rendered possible. Furthermore, by providing a mechanism which enables a user to normally set passages in the device, the evenness in quality of the cells is rendered possible likewise.

Cell culture device

In culture vessels for producing biological samples, it is possible to prevent decrease in a temperature at the time of taking out the culture vessels from an automatic culture apparatus and during delivery of the culture vessels which have been taken out from the automatic culture apparatus. This invention includes a culture vesselholding a biological sample therein, a heat storage portionholding the culture vessel, and a heat insulation portionsurrounding the heat storage portion. The whole circumference or a part of, andof the heat insulation portionis removable depending on an arrangement environment.

Cell culturing device, culturing vessel, and holding vessel

Provided is a cell culturing vessel for holding and culturing cells. It has a first vessel that stores a culture medium and cells or only a culture medium, a second vessel that is placed above the first vessel and stores a culture medium and cells or only a culture medium, a main vessel that holds the first vessel and houses the second vessel, and a lid member that engages with the main vessel. The main vessel has a pressing member that fixes and holds the first vessel in the main vessel and the second vessel is eccentrically held in the first vessel by the pressing member.

Cell-culturing vessel and cell-culturing device using same

The present invention provides a carrier device including a culture vessel and a flow channel, which have a closed structure, for supplying cell liquid or a culture medium into the flow channel; and a method of aseptically injecting liquid, such as the cell or the culture medium, into the culture vessel and the flow channel. The present invention provides a carrier jigincluding a drive base, a culture vessel basethat holds a culture vessel, a culture medium basethat holds a cell bagand the like for the culture medium and the cell, and a detachable flow channel, those of which are held by a liftto be carried to a cell culture device. A part of the flow channeland the cell bagmounted on the carrier jigare put into a clean space. The cell and the culture medium are supplied into the flow channelby using the cell bagand other bags in the clean space, and then, an injection portis closed. The respective bases and the flow channel are simultaneously mounted to the cell culture device by using the carrier jig. Thus, the aseptic cell culture can be realized.

Cell culture device and transport device

There is provided a method for noninvasively evaluating the cell state (proliferation, multi-layering, and differentiation) of a cell sheet as a mimic tissue at the time of culturing the cell sheet. The method is characterized in that an analysis of an amino acid is conducted with the use of the culture supernatant of a cell sheet to monitor a change in the concentration of any amino acid selected from a group of 5-species of amino acids (Ile, Val, Ser, Leu, and Ala), thereby making a determination.

Method for determining cell state and autoanalyzer using said method

Disclosed is a cell culture vessel of the present invention, which is composed of a space enclosed by a housing that supports a medium and a cell attachment part, disposed on the bottom surface of the space, that attaches and supports the cells, the cell attachment part having a cell immobilizing mechanism that guides the cells in the space to the cell attachment part to immobilize there and a cell detachment mechanism that detaches the cells attached in the cell attachment part, the cell immobilizing mechanism having a step of applying a voltage to an electrode disposed in the cell attachment part to generate a heterogeneous electric field in the space, and the cell detachment mechanism having a step of applying a voltage to an electrode disposed in the cell attachment part to induce electrolyte in the space.

The present invention relates to a novel compound having a function of inhibiting ROR&#x3b3; activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.

Pyrazole amide derivative

A cell culture apparatus has four sections, including a cell culture chamber, refrigerator, control unit, and intermediate chamber. The cell culture chamber includes a culture vessel base as a holding member for holding and installing a culture vessel, a microscope for photographing a cell image within the culture vessel, and a drive base which has drive mechanisms such as a pump and a valve to be connected to a flow channel having a closed structure including a tank. With the drive base within the cell culture chamber as the center, the rotatable culture vessel is arranged in the horizontal direction and the refrigerator in which the culture medium base containing the cell fluid and culture medium is installed is arranged in the vertical direction. The arrangement configuration is space-saving and provides a short distance between the instruments.

Cell culture apparatus

Growing community of inventors

Tokyo, Japan

Ryota Nakajima