Sawai Pharmaceutical Co., Ltd.

Ryota Kimata

Naoki Yoshihara

Hiroyuki Yamamoto

Kenji Nozawa

Wataru Izui

A method for producing granules containing a core particle by using a general granulation method is provided. Granules containing a core particle produced by the method are provided. In addition, a pharmaceutical composition and preparation containing the granules containing the core particle are provided. The granulation method according to an embodiment of the present invention granulates by spraying granulation liquid having a mist diameter (D) not more than the particle size (D) of the core particle on a mixture containing a drug substance and a core particle. The granulation liquid may be water. The particle size of the core particle (D) may be larger than the particle size (D) of the drug substance.

Method for producing granules containing a core particle, granules containing a core particle, pharmaceutical composition containing the granules containing the core particle, and preparation containing the pharmaceutical composition

One of the objects of the present invention is to provide a granule capable of sufficiently masking bitterness. Alternatively, one of the objects of the present invention is to provide a preparation containing a granule capable of sufficiently masking bitterness. According to an embodiment of the present invention, a granule is provided including a core substance on which a melt component and an active ingredient are disposed, a gelling substance-containing layer disposed on a surface where the melt component and the active ingredient are disposed, and a hydrophobic polymer-containing layer disposed on a surface of the gelling substance-containing layer.

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Osaka, Japan

Ryota Kimata