Astellas Pharma Gmbh

Ryota Azuma

Mitsuru Yoshida

Toshiro Sakai

Hiroaki Tasaki

Ryo Kojima

Daisuke Tsunashima

Marina Tanaka

Provided is a pharmaceutical composition, which comprises 5-{[(3R)-1-acryloylpyrrolidin-3-yl]oxy}-6-ethyl-3-({4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}amino)-pyrazine-2-carboxamide (hereinafter referred to as 'compound A') or a pharmaceutically acceptable salt thereof, and is stabilized. The pharmaceutical composition comprises compound A or a pharmaceutically acceptable salt thereof, and a pharmaceutical additive having a difference in water activity value of 0.1 or more, and is stabilized.

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Tokyo, Japan

Ryota Azuma