Osaka University

Japan Institute of Leather Research

Ryoko Sato

Kiyotoshi Sekiguchi

Shunji Hattori

Yoh-ichi Koyama

Sugiko Futaki

Hitomi Fujisaki

Shaoliang Li

Sachiko Ezoe

A modified laminin characterized in that a laminin or a heterotrimeric laminin fragment has a collagen binding molecule conjugated to at least one site selected from the &#x3b1; chain N-terminus, the &#x3b2; chain N-terminus and the &#x3b3; chain N-terminus, and an extracellular-matrix material comprising the modified laminin, and collagen and/or gelatin serve as an alternative to Matrigel and are useful as an extracellular-matrix material for the formation of a safe three-dimensional tissue structure for regenerative medicine in humans.

Modified laminin containing collagen binding molecule and use thereof

It is an object of the present invention to provide a Type I-Type IV collagen hybrid gel, which maintains characteristics of a Type IV collagen and is superior in gel strength. It is the Type I-Type IV collagen hybrid gel obtained by mixing 100 to 500 parts by mass of the Type I collagen having fibrosis ability, relative to 100 parts by mass of the Type IV collagen having gelling ability. A three-dimensional structure is formed, where a membrane-like substance by the Type IV collagen is formed onto a fibrous substance by the Type I collagen, so as to be able to provide cell culture environment approximate to a basement membrane of a living body.

Type I-type IV collagen hybrid gel

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Suita, Japan

Ryoko Sato