Takasago International Corporation

Teijin Limited

Kanto Kagaku Kabushiki Kaisha

Other

Nkk Corporation

Research Development Corporation of Japan

Shin-Etsu Chemical Co., Ltd.

Ajinomoto Co., Ltd.

Kaneka Corporation

Takeda Pharmaceutical Company Limited

Daicel Chemical Industries, Ltd.

Ono Pharmaceutical Co., Ltd.

Japan Science and Technology Corporation

Nagoya University

Ge Healthcare Limited

Ryoji Noyori

Hidenori Kumobayashi

Takao Ikariya

Noboru Sayo

Hidemasa Takaya

Takeshi Ohkuma

Susumu Akutagawa

Seizi Kurozumi

Masato Kitamura

Masaaki Suzuki

Kunihiko Murata

Philip Gregory Jessop

Akio Fujii

Takao Saito

Kazuhiko Matsumura

Jun Takehara

Shohei Hashiguchi

Nobuo Seido

Takeaki Katayama

Tetsuo Ohta

Susumu Saito

Kunihiko Tsutsumi

Makoto Emura

Noriyuki Utsumi

Nobuo Yamada

Yi Hsiao

Takaaki Toyoda

Minoru Okayama

Sakaru Suzuki

Akira Yanagisawa

Nobuyuki Uematsu

Toshiyuki Takezawa

Kunisuke Izawa

Kenji Inoue

Satoshi Sugiura

Bengt Langstrom

Masahito Watanabe

Atsuo Hazato

Yasuyoshi Watanabe

Tomoyuki Onishi

Farhad Karimi

Takayuki Hamada

Takaji Matsumoto

Misao Yagi

Takayoshi Torii

Masami Kozawa

Takanao Taketomi

Makoto Harada

Yoichi Yuki

Hideyuki Ikehira

Kazuki Iida

Junichi Hori

Hisashi Doi

Martin F Giles

Kenzo Sumi

Hirofumi Maeda

Yoshio Ueno

Izuru Nagasaki

Katukiyo Sakurai

Nobuhito Kurono

Masanori Fukushima

Christian A Sandoval

Sota Nimura

Makoto Tokunaga

Santosh Agrawal

Takashi Ohkuma

Sunkook Lee

Shigeyoshi Kamohara

Takeshi Okuma

Satsohi Sugiura

Masahiko Hayashi

Takashi Miura

Toru Yokozawa

Eiji Katayama

Masayuki Naruto

Yuki Takada

Shinichi Inoue

Susumo Akutagawa

Katsuaki Toda

Julien Barletta

Noriyuki Kanto Kagaku Kabushiki Kaisha Utsumi

Takeshi 401 Berudomiirusoennigokan Okuma

Kunihiko Kanto Kagaku Kabushiki Kaisha Tsutsumi

Kunihiko Kanto Kagaku Kabushiki Kaisha Murata

Takeaki Kanto Kagaku Kabushiki Kaisha Katayama

Christian A c/o Shanghai Institute Of Org Chemistry Sandval

Takeshi Verudomiru-Soen 2-401 Ohkuma

A hydrogen transfer reaction may be more efficiently promoted by using a metal complex represented by Formula (2):  More specifically, the metal complex enables a hydrogenation reaction of various substrates having a stable carbonyl group or the like to be advanced with a high yield under mild conditions.

Ligand, metal complex containing ligand, and reaction using metal complex containing ligand

Methods and reagents for transition metal-promoted carbonylation via isocyanate using carbon-isotope labeled carbon monoxide are provided. The resultant carbon-isotope labeled compounds are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.

Methods for carbon isotope labeling synthesis by transition metal-promoted carbonylation via isocyanate using azides and carbon-isotope monoxide

A novel ruthenium complex which is a highly efficient catalyst useful for the production of optically active 3-quinuclidinols, and a process for production of optically active 3-quinuclidinols using the ruthenium complex as a catalyst, where the optically active 3-quinuclidinols are useful as an optically active, physiologically active compound utilized in medicines and agrichemicals or as a synthetic intermediate such as a liquid crystal material.

Process for production of optically active quinuclidinols

Disclosed is a method for producing an alcohol from a lactone or a carboxylic acid ester, which enables to produce an alcohol from a lactone or a carboxylic acid ester under relatively mild conditions with high yield and high catalytic efficiency. This method also enables to produce an optically active alcohol from an optically active lactone or an optically active carboxylic acid ester. Specifically disclosed is a method for producing an alcohol by hydrogen reducing a lactone or a carboxylic acid ester in the presence of a catalyst containing ruthenium and a phosphine compound represented by the following general formula (1): wherein Rrepresents a spacer; R, R, R, R, Rand Rindependently represent a hydrogen atom, an alkyl group having 1-12 carbon atoms, an aryl group or a heterocyclic group; and R, R, R, R, Rand Rindependently represent an alkyl group having 1-12 carbon atoms, an aryl group or a heterocyclic group.

Method for producing alcohol by hydrogenating lactone and carboxylic acid ester in liquid phase

A hydrogenation promoter of the present invention is produced by reacting an alkyne compound or an alkene compound, a palladium compound represented by a general formula Pd(II)XL(where L represents a monodentate ligand or a polydendate ligand other than a phosphorus-containing ligand (when two or more Ls are present in the compound, the Ls may be the same or different), X represents an anionic group, j represents a value determined according to the valence of X so that Xhas a valence of &#x2212;2 as a whole, and k represents an integer in the range of 0 to 4), and a base in an organic solvent. Specifically, The hydrogenation promoter of the invention includes palladium nanoparticles containing the alkyne compound or the alkene compound as an agglomeration-preventing agent.

Hydrogenation promoter, hydrogenation catalyst, and process for producing alkene compound

A sulfonate catalyst represented by the formula below and a ketone compound are placed in a solvent, and the ketone compound is hydrogenated by mixing in the presence of hydrogen to produce an optically active alcohol. 

Sulfonate catalyst and method of producing alcohol compound using the same

A tert-alkyl ketone, pinacolone was hydrogenated under pressurized hydrogen in the presence of a ruthenium complex (S)-1 and a base, and corresponding (S)-3,3,-dimethyl-2-butanol was thereby obtained in 100% yield and 97% ee 

Ruthenium complex and process for producing tert-alkyl alcohol therewith

A method for producing optically active compounds is disclosed. The method is highly practical for producing optically active compounds useful for various utilities such as intermediates for synthesizing pharmaceutical agents, liquid crystal materials and agents for optical resolution.

Method for producing optically active compounds

A process of preparing an optically active halohydrin compound characterized by comprising asymmetric hydrogen transfer reduction of an &#x3b1;-haloketone compound in the presence of a group 9 transition metal compound having a substituted or unsubstituted cyclopentadienyl group and an optically active diamine compound. The asymmetric hydrogen transfer reduction is preferably conducted in the presence of a base.

Process for producing optically active halohydrin compound

Alcohols are produced in a practical and advantageous method, by the hydrogenation of a carbonyl compound under mild conditions, by reacting the carbonyl compounds with hydrogen in the presence of a bipyridyl derivative, a group VIII transition metal complex, and a base, or by reducing a carbonyl compound in the presence of a bipyridyl derivative, a group VIII transition metal complex, a base, and an alcoholic solvent.

Processes for the preparation of alcohols

The invention provides a metal complex comprising a ligand and a metal. The ligand is an aminophosphine compound represented by the following formula (1)

Complexes of transition metals with novel axial asymmetric compounds as the ligands

This document describes a novel and practically excellent process for the preparation of optically active compounds, such as optically active alcohols or amines which are useful for various applications, for example, as synthetic intermediates of pharmaceuticals, liquid crystal materials, and reagents for optical resolution, wherein a hydrogen transfer type asymmetric reduction is carried out in the presence of both a transition metal complex and an optically active nitrogen compound or a transition metal complex having an optically active nitrogen compounds as an asymmetric ligand, and a hydrogen-donating organic or inorganic compound.

Process for preparing optically active compounds

Formic acid or derivatives thereof are produced from non-toxic carbon dioxide in the supercritical state, using it as raw materials, without using solvents, and at a high efficiency owing to a high reaction velocity, by reacting said carbon dioxide and an active hydrogen group-containing compound.

Method for producing formic acid or its derivatives

A process whereby 4-t-butylcyclohexanol with a high content of the cis-isomer, which is useful as a perfume ingredient, can be economically produced on an industrially available scale at a low cost. The process comprises hydrogenating 4-t-butylcyclohexanone by using a specific ruthenium-phosphine complex as a catalyst in the presence of a base containing an alkali metal and an alkylenediamine having from 1 to 6 carbon atoms.

Process for producing cis-4-t-butylcyclohexanol

Method for producing formic acid of its derivatives

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Aichi, Japan

Ryoji Noyori