Canon Kabushiki Kaisha

The University of Tokyo

Microbial Chemistry Research Foundation

Ryoichi Matsuda

Takeshi Miyazaki

Kohei Watanabe

Tomoyo Fujiyama

Osamu Kanome

Kenji Nishiguchi

Yoshikazu Takahashi

Akihiro Taguchi

Daishiro Ikeda

Masataka Shiozuka

Masafumi Matsuo

Yoshio Hayashi

Yoshiaki Nonomura

Atsushi Nishida

Fumika Yakushiji

Yuri Yamazaki

Akira Wagatsuma

Qsamu Kanome

[Problem] Provision of a novel compound having read-through activity and a drug for the treatment of nonsense mutation-type disease containing this compound. [Solution] A compound represented by the following general formula (1): and a pharmaceutical composition containing this compound.

Compound having read-through activity

A readthrough inducing agent for inducing readthrough of a premature stop codon generated by nonsense mutations, the readthrough inducing agent comprising a compound having a structure expressed by the following Structural Formula (A), and a drug for treating a genetic disease caused by nonsense mutations, the drug comprising the readthrough inducing agent. 

Readthrough inducing agent and drug for treating genetic disease caused by nonsense mutation

The present invention provides cellular screening substrata which can be formed in simple processing steps. The cellular screening substrata can be formed which are characterized in that plural cellular screening substances are positioned and immobilized at predetermined positions on a base by micro-droplet discharging means, and plural areas having different cellular screening functions are formed thereon.

Manufacturing process for cellular screening substratum, resultant substratum, and method and apparatus for screening

A cell culture substrate having at least one area for culturing a cell on a substrate, characterized in that the culturing area comprises an area releasably holding a biologically active substance having a biological activity to the cell and an area for immobilizing a biologically active substance having a biological activity to the cell.

Substrate for cell culture, producing method thereof and screening method for cell culture conditions utilizing the same

The invention provides a biologically active substance transfer sheet which can be formed with simple steps, a cell culture kit which comprises a cell culture plate and a biologically active substance transfer sheet, a producing method therefor, and a method for screening cell culture conditions with cells. The transfer sheet is prepared by providing biologically active substances having biological activity in plural areas on a sheet base, and biologically active substances are supplied from the sheet to culture regions provided on the plate.

Biologically active substance transfer sheet, cell culture kit constituted of cell culture plate and biologically active substance transfer sheet, producing method thereof and method for screening cell culture conditions utilizing the same

The present invention relates to a substrate for cell culture capable of controlling at least one function selected from adhesion, proliferation, differentiation, survival, maintenance of undifferentiated state, and apoptosis of a cell. The substrate comprises an immobilization area of controlling substances involved in at least one of the functions of adhesion, proliferation, differentiation, survival, maintenance of undifferentiated state and apoptosis of cells, for example: and the areas are formed by supplying a liquid containing the controlling substances to the substrate by small microdroplet ejection means and immobilizing the controlling substance on the substrate.

Substratum having a pattern of cell-culture controlling substance

Transfer sheet for transferring biologically active substance to culture plate

Growing community of inventors

Tokyo, Japan

Ryoichi Matsuda