Daiichi Sankyo Company, Limited

Ryoichi Hayakawa

Gaku Sekiguchi

Shuichi Yada

Hideki Yano

Atsutoshi Ito

Yoshihiro Hara

An object of the present invention is to provide a pharmaceutical composition having abuse deterrent properties and thereby prevent the abuse of a pharmacologically active component by an abuser (abuse through snorting, abuse through injection, or abuse through snorting or injection of a temporarily extracted drug). The present invention provides a pharmaceutical composition having abuse deterrent properties that possesses both a physical barrier and a chemical barrier to being abused by an abuser, a method for producing the same and a method for using the same.

Pharmaceutical composition having abuse deterrent properties

Provided are an orally disintegrating tablet that quickly disintegrates when it is placed in the mouth or put into water, provides favorable taste, has a sufficient hardness in general production, transportation and use and is excellent in terms of storage stability, and a process for the production of the same which is excellent in terms of industrial production. An orally disintegrating tablet containing a drug, a crystalline cellulose having a bulk density of 0.23 g/cmor less (preferably from 0.10 g/cmto 0.23 g/cm), a sugar alcohol and a pregelatinized starch.

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Yokohama, Japan

Ryoichi Hayakawa