Eisai Company, Limited

Genox Research, Inc.

Japan As Represented by General Director of Agency of National Center for Child Health & Development

Eisai Inc.

Ryoichi Hashida

Isao Yamatsu

Takeshi Suzuki

Kenichi Chiba

Hiroshi Shirota

Shinya Abe

Toshihiko Kaneko

Hiroyuki Yoshimura

Shigeru Souda

Yoshimasa Machida

Shuhei Miyazawa

Shigeki Hibi

Seiichiro Nomoto

Naoyuki Shimomura

Katsuya Tagami

Yasushi Okamoto

Tetsuya Kawahara

Kenzo Muramoto

Richard S Clark

Koukichi Harada

Kazuo Okano

Makoto Okita

Kouichi Katayama

Takashi Inoue

Hideki Ono

Masayuki Tanaka

Hideto Ohhara

Masaki Goto

Toru Horie

Takashi Mori

Hideki Sakurai

Yuji Sugita

Kenichi Kusube

Hirohisa Saito

Shinji Kagaya

Takeshi Nagasu

Kaoru Ogawa

Tomoko Fujishima

Gozoh Tsujimoto

Eiki Takahashi

Yoshihiro Yayoi

Hirsohi Shirota

Differential expression of genes whose expression is different in the activated eosinophils of atopic dermatitis patients was measured by comparative analysis using a gene chip. As a result, the TR3 and TINUR genes, whose expression is significantly elevated in activated eosinophils, were successfully identified. The present inventors discovered that these genes can be used to test for allergic disease and to screen candidate compounds for therapeutic agents for allergic disease.

Methods of testing for allergic diseases, and therapeutic agents for treating same

The differential display method was used to search for a gene whose expression level in eosinophils collected from patients with atopic dermatitis differs in the exacerbation stage and in the remission stage. As a result, gene '2090-05' showing a significant increase in expression in eosinophils of patients in the remission stage was isolated. This gene is usable in testing for an allergic disease and screening for a candidate compound for a therapeutic agent therefor an allergic disease.

Method of testing for allergic diseases

Genes whose expression differ between that in eosinophils collected from atopic dermatitis patients of the exabartation stage and those of the remission stage were searched via a differential display method. As a result, NOR-1 (MINOR) gene was successfully identified whose expression significantly increased in eosinophils of patients in the remission stage, a stage associated with a decrease of eosinophils. The present inventors discovered that the gene can be successfully employed in testing for allergic diseases and screening for candidate compounds for therapeutic agents.

Method of testing for atopic dermatitis by measuring expression of the NOR-1 gene

Naphthalene derivatives of the formula: ##STR1## wherein R.sup.1, represents a hydrogen atom, a lower alkyl group or an acyl group; R.sup.2 independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a cycloalkyl group, a cycloalkylalkyl group, a hydroxyl group, an aryl group which may be substituted, an arylalkyl group whose aryl group may be substituted, a heteroaryl group, or a heteroaryllakyl group; R.sup.3 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, an aryl group which may have a substituent, an arylalkyl group whose aryl group may be substituted, an arylalkenyl group whose aryl group may be substituted, a cycloalkyl group, an alkoxyalkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxyl group, a carboxyalkyl group, an aminoalkyl group, or a cyano group; R.sup.6 is C.sub.1-6 alkyl; and m is 0 or an integer of from 1 to 2 useful in treating autoimmune diseases are disclosed.

Naphthalene derivative

Compounds of the formula: ##STR1## where R.sup.1 is a hydrogen atom or a lower alkyl group;

Naphthalene derivatives

A naphthalene derivative having the formula is new and useful for medicine. ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an acyl group;

The present invention relates to a naphthalene derivative. More particularly, it relates to a naphthalene derivative exhibiting an excellent activity as a drug.

A naphthalene derivative having the formula is new and useful for medicine. ##STR1## [wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an acyl group;

Growing community of inventors

Tsukuba, Japan

Ryoichi Hashida