Nippon Telegraph and Telephone Corporation

In-silico Sciences, Inc.

Ryoichi Arai

Hideaki Umeyama

Yasunaga Mitsuya

Yoshiaki Watanabe

Akio Mitamura

Tetsuo Mikazuki

The present invention is directed to serve ligand screening apparatuses, ligand screening methods, programs and a recording medium for studying the binding analysis between a receptor including an induced-fit type receptor and a ligand. First, analysis and calculation of normal mode are conducted, and then fluctuation of a dihedral angle of a main chain in a steady state is calculated. Then by carrying out a molecular dynamic calculation while imposing constraint on each atom based on the fluctuation, a dynamic structure of the receptor is predicted more accurately. By using the dynamic structure obtained in the molecular dynamic calculation and an interaction function, receptor/ligand binding which is also applicable to an induced-fit type receptor is predicted with high accuracy.

Ligand searching device, ligand searching method, program, and recording medium

A head positioning system on a recording medium includes a recording medium having a periodic arrangement of data tracks and servo tracks wherein the periodic arrangement having a predetermined period includes N.sub.d (N.sub.d is an integer equal to or larger than 1) number of data tracks and N.sub.s (N.sub.s is an integer equal to or larger than 2) number of servo tracks, the servo tracks having single phase servo patterns, alternatively recorded thereon, a multi-head carrying a plurality of head elements disposed in a direction perpendicular to the tracks, so that the distance between head elements is (N.sub.h +1/M)P where N.sub.h is an integer equal to or larger than O, M is an integer equal to or larger than 2, and P is a track pitch, wherein the multi-head is movable in a direction generally perpendicular to the direction of the tracks, means for selecting a servo head for reading servo tracks and a data head for reading data tracks from the head elements during a seek operation, wherein a selected servo head is selected to reproduce a servo pattern from a servo track and a selected data head is determined based on the selected servo head, and wherein the multi-head is positioned on a servo track in every 1/M track pitch of movement.

Head positioning system for positioning a multiple head with respect to

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Saitama, Japan

Ryoichi Arai