Astellas Pharma Gmbh

Yamanouchi Pharmaceutical Company Ltd.

Ryo Naito

Makoto Takeuchi

Yoshinori Okamoto

Yasuo Isomura

Masahiko Hayakawa

Ken Ikeda

Yasuhiro Yonetoku

Junji Miyata

Masakatsu Kawakami

Noriyuki Kawano

Atsushi Ichikawa

Souichirou Kawazoe

Akio Kamikawa

Ippei Sato

Issei Tsukamoto

Akira Toyoshima

Toru Asano

Kazuyuki Hattori

Eiichi Nakai

Masaki Yokota

Hiroyuki Hisamichi

Kazuhito Tanabe

Akiko Orita

Susumu Igarashi

Hiroyuki Kanoh

Masato Kobori

The present invention relates to a novel 2-phenylpyridine derivative or a salt thereof, wherein the pyridine ring is substituted with a carboxyl group or the like and the benzene ring has an electron-withdrawing group such as a cyano group and an electron-donating group such as a substituted alkoxy group at the same time. Since the compound of the invention has good xanthine oxidase-inhibitory action and uric acid-lowering action and does not have a structure derived from nucleic acid, the compound has advantages of high safety and excellent effects as compared with conventional compounds and is useful as a therapeutic or preventive agent for hyperuricemia, gout, inflammatory bowel diseases, diabetic kidney diseases, diabetic retinopathy, or the like.

2-phenylpyridine derivative

The present invention relates to a 2-phenylthiophene derivative or a salt thereof, wherein the thiophene ring is substituted with a carboxyl group or the like and the benzene ring has an electron-withdrawing group such as a cyano group and an electron-donating group such as a substituted alkoxy group at the same time. Since the compound of the invention has good xanthine oxidase-inhibitory action and uric acid-lowering action and does not have a structure derived from nucleic acid, the compound has advantages of high safety and excellent effects as compared with conventional compounds and is useful as a therapeutic or preventive agent for hyperuricemia, gout, inflammatory bowel diseases, diabetic kidney diseases, diabetic retinopathy, or the like.

2-phenylthiophene derivative

As a result of an effort made by us for the purpose of developing a therapeutic agent having a bone formation-stimulating effect by promoting the functions of osteoblasts, the present inventors discovered that a certain nitrogen-containing heterocyclic compound exhibits a potent bone formation-stimulating effect on the osteoblast and thus can serve as an excellent prophylactic or therapeutic agent against a metabolic bone disease, whereby establishing the present invention. Thus, the present invention provides a 3,6-disubstituted 1,2,4-triazolo[4,3-b]pyridazine compound or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition comprising such a compound and a pharmaceutically acceptable carrier, especially a bone-forming agent.

Nitrogen-containing heterocyclic compound

Pyrimidine-5-carboxamide derivatives

Quinuclidine derivatives represented by general following general formula (I), salts, N-oxides or quaternary ammonium salts thereof, and medicinal compositions containing the same.

Quinuclidine derivatives and medicinal composition thereof

Growing community of inventors

Chuo-ku, Japan

Ryo Naito