Kureha Corporation

Ryo Matsui

Shigeyuki Kikumoto

Toru Yamazaki

Masahiro Ono

Shigeru Suzuki

Mikiro Yanaka

Atsushi Saitou

Kunitaka Hirose

Yoshiyuki Takemura

Haruka Takahashi

Sei Kumakura

Masashi Yamamoto

Tomohiro Sawa

Provided is an ester of 3-[(4-dipropylamino-butyl)(4-{[(1H-imidazole-2-ylmethyl)(1-methyl-1H-imidazole-2-ylmethyl)amino]methyl}benzyl)amino]propionic acid which is easily hydrolyzed in serum. The amine compound of the present invention is an ester compound represented by general formula (1). (In general formula (1), n is 1-4, and Rand Rrepresent an alkyl group having 1-3 carbon atoms.) 

Amine compound and use for same

Amine compounds represented by Formula () are efficacious against diseases such as a viral infectious disease with HIV, rheumatism, and cancer metastasis: 

Amine-based compound and use thereof

It is intended to provide novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism and cancer metastasis. Namely, amine compounds represented by the following general formula (1):  In a typical case, A1 and A2 represent each an optionally substituted monocyclic or polycyclic aromatic heterocycle; W represents cyclic C3-10 alkylene, an optionally substituted monocyclic or polycyclic aromatic heterocycle, a monocyclic or polycyclic aromatic ring or a partly saturated polycyclic aromatic ring; X represents O, CH2, C(&#x2550;O) or NR11; and D is a group represented by the following general formula (4) or (6).  In the formula (6), Q represents a single bond, S, O or NR12; and Y is a group represented by the following general formula (7). z represents an optionally substituted monocyclic or polycyclic aromatic ring. In the formula (6), B represents NR25R26. In the above formulae, R1 to R26 each represents hydrogen, alkyl, alkenyl or alkynyl.

Amine compound and use thereof

Novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism, and cancer metastasis include compounds represented by the following general formula (1), a pharmacologically acceptable salt thereof, or a prodrug thereof: wherein each of n, n, and nis an integer of 1; each of R, R, R, R, R, and Ris independently a hydrogen atom; Ais imidazole; Ais imidazole or imidazole substituted with an alkyl group; W is a phenyl group or naphthyl group; X is CH; D is a group represented by -Q-Y&#x2014;B, wherein Q is NRand Ris a hydrogen atom or an alkyl group; Y is (CH)mand mis an integer of 2 to 4; and B is N(RR), wherein each of Rand Rare independently a hydrogen atom, a C&#x2013;Calkyl group or a C&#x2013;Ccycloalkyl group.

Amine compounds and use thereof

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Tokyo, Japan

Ryo Matsui