Acucela Inc.

University of Washington

Ryo Kubota

Amitava Gupta

Philip M Buscemi

Matthias Pfister

Vladimir Aleksandrovich Kuksa

Ian L Scott

Mark W Orme

Stefan Bauer

Karim Haroud

Julien Sauvet

Urban Schnell

Stefan Troller

Feng Hong

Lukas Scheibler

Hans Bernhard

Patrizia Weber

Jean-Noël Fehr

Stephan Wyder

Christian Oggenfuss

Beat Wyss

Moritz Haeberli

Jennifer Lynn Gage

Thomas L Little, Jr

Massimo Pinazza

James Phillips

Pascal Loser

Ben Crook

Jim Niebanck

Anna S Gall

Jean-Noel Fehr

Qin Jiang

Lana Michele Rossiter

Claes Olof Bavik

Benjamin Crook

Gordon Frederick Maccabee

Kevin F McGee, Jr

Ferry Widjaja

Alexander Holzer

Thomas Little

Glenn Noronha

Arkady Selenow

Susan Hayes Henry

Nabin Joshi

Steven Ali

Vladimir Aleksandrovich Kuska

Thomas A Reh

Alain Saurer

Cyril Stoller

Nancy Boman

Andrew J Fischer

Praveenth Sanmugarajah

Jonas Butscher

Marco Burgener

An apparatus to treat refractive error of the eye comprises one or more optics configured to project stimuli comprising out of focus images onto the peripheral retina outside the macula. While the stimuli can be configured in many ways, in some embodiments the stimuli are arranged to decrease interference with central vison such as macular vision. The stimuli can be out of focus images may comprise an amount of defocus within a range from about 3 Diopters ('D') to about 6 D. In some embodiments, the brightness of the stimuli is greater than a brightness of background illumination by an appropriate amount such as at least 3 times the background brightness. In some embodiments, each of a plurality of stimuli comprises a spatial frequency distribution with an amplitude profile having spatial frequencies within a range from about range of 1×10to 2.5×10cycles per degree.

Projection of defocused images on the peripheral retina to treat refractive error

A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.

Device for projecting images on the retina

Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

Miniaturized mobile, low cost optical coherence tomography system for home based ophthalmic applications

An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. The scan pattern is a continuous pattern that includes a plurality of lobes. The measurement beam may be caused to move on the retina by the motion of a mirror that intercepts and redirects the measurement beam. The mirror position may be altered by the application of a drive signal to one or more actuators that respond to the drive signal by rotating the mirror about an axis or axes.

Scan pattern and signal processing for optical coherence tomography

A source of light energy such as a source of violet light energy is coupled to a structure configured to contact the eye. The light source and structure are arranged to provide therapeutic amounts of violet light energy to the eye in order to inhibit the progression of refractive error such as myopia. The light source can be configured in many ways and may comprise a radioisotope and a phosphorescent material. The structure configured to contact the eye may comprise a contact lens or an implant.

Method and apparatus for treating refractive error of the eye

An electronic case for electronic spectacles may include a base comprising a cavity formed therein. A first spectacle retention device may be located within the cavity. The first spectacle retention device may be configured to retain spectacles. An electrical control system may be included. An electrical connector may be configured to couple the electrical control system in electronic communication with the spectacles.

Electronic case for electronic spectacles

A soft contact lens comprises a plurality of light sources coupled to a plurality of optical elements. The plurality of light sources and the plurality of optical elements are embedded in a soft contact lens material. Each of said plurality of optical elements generates an image focused in front of a peripheral retina of a wearer. In some embodiments, each of the images is focused at a distance in front of the peripheral retina at a location, and each of the images comprises a depth of focus and a spatial resolution. The depth of focus can be less than the distance, and the spatial resolution greater than a spatial resolution of the peripheral retina at the location.

Optical designs of electronic apparatus to decrease myopia progression

A contact lens may include a body of contact lens material extending between a first surface and a second surface. An electromechanical component may be supported in the contact lens material between the first surface and the second surface. A support comprising a plurality of pillars may be formed of the contact lens material and may extend from at least one of the first surface and the second surface to the electromechanical component.

Supporting pillars for encapsulating a flexible PCB within a soft hydrogel contact lens

An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.

Stick on devices using peripheral defocus to treat progressive refractive error

Systems, devices, apparatuses and methods for an active projection system that may be incorporated into spectacles, contact lenses or provided as an add-on layer to existing spectacles or lenses. The active projection system operates to generate a stimulus or stimuli for viewing by a person's eye. The stimulus or stimuli creates an image that is defocused in front of the person's retina and can assist in slowing or stopping the progression of myopia or other refractive errors in the person.

Apparatus for the treatment of refractive error using active stimulation

An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. Measurement data may be processed using a decurving process to enhance the resolution of the ILM layer and provide improved determinations of retinal thickness.

System and method for optical coherence tomography a-scan decurving

An apparatus to treat refractive error of an eye comprises an electroactive component configured to switch between a light scattering or optical power providing configuration to treat refractive error of the eye and a substantially transparent configuration to allow normal viewing. The electroactive component can be located on the lens away from a central axis of the lens to provide light to a peripheral region of the retina to decrease the progression of myopia. The electroactive component can be located on the lens away from the central axis of the lens in order for the wearer to view objects through an optical zone while the electroactive component scatters light. The electroactive component can be configured to switch to the substantially transparent configuration to allow light to pass through the electroactive component and to allow the lens to refract light to correct vision and allow normal viewing through the lens.

Electro-switchable spectacles for myopia treatment

Embodiments of the present disclosure are directed to systems, apparatuses and methods for prediction, diagnosis, planning and monitoring for myopia and myopic progression. In some embodiments, one or more refractive properties of the eye is determined for each of a plurality of retinal locations of the eye. The plurality of locations may comprise a central region, such as a fovea of the eye, or non-foveal region such as a peripheral region or a region of the macula outside the fovea. Measuring the refractive properties of the eye for the plurality of locations may be helpful in diagnosing myopia and other ocular conditions by providing the refractive properties of the eye for locations away from the fovea, such as the peripheral retina.

Myopia prediction, diagnosis, planning, and monitoring device

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Seattle, WA, United States of America

Ryo Kubota