Agro-kanesho Co., Ltd.

Ryo Aizawa

Koichi Araki

Itaru Okada

Toshiki Fukuchi

Masahiro Hatamoto

The present invention provides a method for producing a 2-aminonicotinic acid benzyl ester derivative. The method includes, as a step, reacting a 2-aminonicotinic acid derivative represented by the formula [I], wherein Rrepresents a hydrogen atom or a Cto Calkyl group and M represents an alkali metal, with a benzyl derivative represented by the formula [II], wherein Rrepresents, for example, a hydrogen atom or a halogen atom, A represents, for example, a nitrogen atom, X represents a halogen atom, and Y represents, for example, an oxygen atom, in an aromatic hydrocarbon solvent in the presence of a phase transfer catalyst or a tertiary amine.

Method for producing 2-aminonicotinic acid benzyl ester derivative

The present invention provides a method for producing 2-amino-6-methylnicotinic acid represented by formula [I], wherein the production method comprises: (a) reacting 2-chloro-3-cyano-6-methylpyridine represented by formula [II] in an ammonia aqueous solution to obtain a reaction solution containing 2-amino-6-methylnicotinamide represented by formula [III]; and (b) removing the ammonia from the reaction solution, then reacting the 2-amino-6-methylnicotinamide represented by formula [III]with a base to produce 2-amino-6-methylnicotinic acid represented by formula [I]. 

Method for producing 2-amino-6-methylnicotinic acid

The present invention provides a method of producing a 2-aminonicotinic acid benzyl ester derivative at a high yield and with a high purity. By reacting a benzyl halide derivative with a 2-aminonicotinic acid derivative in a polar solvent in the presence of a prescribed base, it is possible to obtain a 2-aminonicotinic acid benzyl ester derivative at a high yield and with a high purity.

Method of producing 2-aminonicotinic acid benzyl ester derivatives

The present invention provides a bactericide containing a 2-aminonicotinic acid ester derivative as an active ingredient. The active ingredient is represented by the following formula [I]: (wherein, Rrepresents a hydrogen atom or a C-Calkyl group, Rrepresents a hydrogen atom or a C-Calkyl group, Rand Rmay be combined together to form an alkylene chain, Rrepresents a hydrogen atom or a C-Calkyl group, Rrepresents a hydrogen atom, a cyano group or a C-Calkyl group, Rand Rindependently represent a hydrogen atom, a halogen atom, a C-Calkyl group, a C-Calkoxy group, a C-Calkylthio group, a C-Calkylsulfinyl group, a C-Calkylsulfonyl group, a nitro group, a cyano group, a C-Chaloalkyl group, a C-Chaloalkoxy group or a C-Chaloalkylthio group, A and B independently represent a methine (CH) group or a nitrogen atom).

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Tokorozawa, Japan

Ryo Aizawa