3m Innovative Properties Company

Kindeva Drug Delivery, L.p.

3m Innovative Properties

Ryan Patrick Simmers

Jon A Kirschhoffer

Eric R Cybulski

Scott D Gullicks

Bernard A Gonzalez

Mark F Schulz

Craig S Moeckly

Bruce R Broyles

Jeffrey Robert Janssen

Paul A Martinson

Chin-Yee Ng

Jameel R Qiblawi

Erik J Johnson

Dennis G Berry

Dennis R Keicher

Scott A Burton

Jeffrey R Janssen

Richard Rhys Mathias

Jia Hu

Jonathan M Lise

Thomas G Skulley

Thomas J Gilbert

Steven P Gowers

Ian R Owen

Sean M Burke

Jenny L Hicks

Robert G M Selby

Daniel G T Strange

Marc Peuker

Lloyd S Vasilakes

Sigurdur Thorsteinsson

Nathan A Abel

Mauro Porcini

Robert L W Smithson

Gregory R Ley

John G Petersen

Robert A Harkins

Larry Allan Schleif

Michael J Frits

Emir Jelovac

Franklyn L Frederickson

Christopher J Miller

Steven E Turch

Przemyslaw Pawel Markowicz

Stanley Rendon

Kenneth A P Meyer

Mathias Bertl

Kieron Hiuhon Tse

Kristen J Hansen

Martin Preininger

Percy T Fenn

Jerome E Gysbers

Daniel H Berg

Catherine G Kriske

Michael B Sivigny

Andreas Syrek

Applicator

Methods, apparatus, devices and systems for mixing and dispensing multi-component materials. The mixing and dispensing may be performed using a mobile, enclosed dispenser that can be used to supply a mixed multi-component material at the point of use. In some embodiments, the components to be mixed into the multi-component material may be supplied in cartridges.

Mixing and dispensing curable multi-component materials

An applicator and method for applying a microneedle array to skin. The applicator can include a body having a first portion and a second portion defining a cavity, the second portion having a slot presented on an outside surface for insertion of the microneedle array into the cavity. The first portion and the second portion are slidable relative to one other along an axis enabling the body to be in an unprimed configuration and a primed configuration. The applicator further includes a door operable with the second portion, the door being movable from a first door position to a second door position, wherein when the device is in the unprimed configuration, the door at least partially obstructs the slot and access into the cavity. When the device is in the primed configuration, the door does not obstruct the slots and enables access into the cavity.

Applicator for applying a microneedle array to skin

The present disclosure relates to apparatus, assemblies, combinations, and methods for infusing fluids by hollow microneedles.

Hollow microneedle arrays

A micro-needle device for delivering a dental local anesthetic that includes a micro-needle array and a hollow spheroid shaped container. The micro-needle array has a base and two or more elongate micro-needles. The elongate micro-needles have an interior surface defining an opening through the elongate micro-needle and the base has a first major surface and a second major surface through which the opening of the elongate micro-needle passes to provide a passage across the base. The hollow spheroid shaped container includes an inside surface, where the first major surface of the base and the inside surface of the hollow spheroid shaped container define a volume that is in fluid connection with each opening of the two or more of the elongate micro-needle. This allows the dental local anesthetic to flow from the volume of the micro-needle device through the opening of the two or more of the elongate micro-needle.

Micro-needle device

An article comprising at least one microneedle is provided. The article can comprises a first side and a second side opposite the first side. The first side comprises a central cavity portion and a platform portion, with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedle comprises a body comprising an outer surface; a base segment having a base and a first shape; a tip segment having a tip and a second shape, wherein the second shape is distinct from the first shape; a transition plane that delineates the base segment and the tip segment; and a central axis. Methods of using the article are also provided.

Article comprising a microneedle and methods of use

An applicator and method for applying a microneedle device to a skin surface. The applicator can include a first portion comprising a microneedle array, and a second portion coupled to the first portion via a connector. The connector can be configured to yield or fracture by changing from a first state in which the connector is intact to a second state in which the connector is yielded or fractured when a threshold application force is applied to at least one of the first portion and the second portion in a direction substantially perpendicular with respect to the first portion. The method can include pressing the applicator in a direction substantially perpendicular to the first portion to press the microneedle array into the skin surface until the threshold application force is met or exceeded and the connector is changed to its second state.

Force-controlled applicator for applying a microneedle device to skin

An article () comprising at least one microneedle () is provided. The article comprises a first side () and a second side () opposite the first side. The first side comprises a central cavity portion () and a platform portion (), with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedle comprises a body comprising an outer surface (); a base segment () having a base () and a first shape; a tip segment () having a tip and a second shape, wherein the second shape is distinct from the first shape; a transition plane () that delineates the base segment and the tip segment; and a central axis (). Methods of using the article are also provided.

Microneedle array and method of use

An article having at least one microneedle () is provided. The microneedle includes a base (), an elongated body () having a central axis () and a body diameter (), a tip portion (), a first channel (), and a second channel (). The tip portion includes a tip (), a beveled surface (), and a bevel opening () in the beveled surface. The first channel extends axially from the bevel opening through at least a portion of the elongated body and has a first wall that is substantially aligned with the central axis. The second channel extends radially from the first channel to the bevel opening and has a second wall that is oriented substantially orthogonal to the central axis. The first channel and second channel merge to form the bevel opening.

Hollow microneedle with bevel opening

An article having at least one microneedle () is provided. The microneedle includes a base (), an elongated body () having a central axis () and a body diameter (), a tip portion (), and a hollow channel (). The a tip portion includes a tip (), a first bevel face () oriented diagonally with respect to the central axis and extending through at least 75% of the body diameter, a second bevel face () oriented substantially perpendicular to the central axis and intersecting the first bevel face, and a bevel opening defined by a first edge () of the first bevel face and a second edge () of the second bevel face. The hollow channel extends axially into the body from the bevel opening ().

Hollow microneedle with beveled tip

An articlecomprising at least one microneedleis provided. The article comprises a first sideand a second sideopposite the first side. The first side comprises a central cavity portionand a platform portion, with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedlecomprises a body comprising an outer surface; a base segmenthaving a base and a first shape; a tip segmenthaving a tipand a second shape, wherein the second shape is distinct from the first shape; a transition planethat delineates the base segment and the tip segment; and a central axis.

Article comprising a microneedle

The present application provides articles () having a polymeric substrate () with a plurality of solid and/or hollow microneedles () extending therefrom. Each solid microneedle is formed by a molding process and the microneedle has body with first () and second cavities () extending therein. The hollow microneedles are formed by removing a portion of the polymeric material disposed between the first cavity and the second cavity. A method for determining the location of a microneedle in an article comprising solid microneedles is also provided. The method comprises directing electromagnetic radiation toward an article comprising a plurality of microneedles and imaging the article.

Article with hollow microneedles and method of making

An articlehaving a first sidethat has a central portiondefined by a first edge, a microneedle-free peripheral portionthat substantially surrounds the central portion, and a plurality of spaced-apart hollow microneedles. Each microneedle has a body that includes an outer surface; a base segmenthaving a baseand a first shape; a tip segmenthaving a tipand a second shape, wherein the second shape is distinct from the first shape; a transition planethat delineates the base segment and the tip segment; and a central axis. An angle, defined by an intersection of the central axis of at least one microneedle and a shortest line extending from the first edge and through the transition plane of the at least one microneedle, is less than about 50&#xb0;.

Hollow microneedle array article

Growing community of inventors

Fargo, ND, United States of America

Ryan Patrick Simmers