Providence Health & Services - Oregon

Agonox, Inc.

Ryan Montier

Andrew D Weinberg

Thomas Duhen

Rebekka Duhen

Methods are disclosed for treating a subject with a tumor. These methods include administering to the subject a therapeutically effective amount of CD8CD39CD103T cells. Methods also are disclosed for isolating a nucleic acid encoding a T cell receptor (TCR) that specifically binds a tumor cell antigen. These methods include isolating CD8CD39CD103T cells from a sample from a subject with a tumor expressing the tumor cell antigen, and cloning a nucleic acid molecule encoding a TCR from the CD8CD39CD103T cells. In addition, methods are disclosed for expanding CD8CD39CD103T cells. In additional embodiments, methods are disclosed for determining if a subject with a tumor will respond to a checkpoint inhibitor. The methods include detecting the presence of CD8CD39CD103T cells in a biological sample from a subject.

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Camas, WA, United States of America

Ryan Montier