Globus Medical, Inc.

Unl Holdings LLC

Amgen Inc.

Unitract Syringe Pty Ltd

Eli Lilly and Company

Ryan Michael Agard

Sean S Suh

Ian B Hanson

Paul F Bente, Iv

Nicholas J Ciccarelli

Matthew J Clemente

Sean M O'connor

Kevin Lee Bokelman

Jason Pastor

Samuel Yoon

Mark Weiman

Chad Glerum

Damien O'Halloran

Michael Moretti

John Christian Love

Samuel Petersheim

Kun-Chi Wu

Daniel Waite

Sheldon B Moberg

Scott Robert Gibson

Daniel Davenport

Margaux Frances Boyaval

Daniel Shawn Codd

Rajan Ramaswamy

Scott Beaver

Mark A Destefano

Gautam N Shetty

Basel Hasan Taha

Rory Palmer

Robert Decker

Christopher Edward Hatch

Wael Mismar

Thomas Clark Pearson

Sudeshna Dutta Ray

Shaun Robert Devitt

Jerome Olivas

Matthew Wayne Janke

Justin Harris

Owen Ryan

Alexis Dechelette

Michael Gammelager

Mads Hansen

Clive Smith

Valerio Mazzon

Paul F Bente

John C Love

Iv Bente Paul F

Kevin Bokelman

Nicholas Joseph Ciccarelli

Daniel Scott Davenport

Andrew Nathan King

Paul F Bente Iv

Sean M O`CONNOR

Disclosed herein is a wearable drug delivery device including a container filled at least partially with a drug including at least one of a PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) specific antibody, a granulocyte colony-stimulating factor (G-CSF), a sclerostin antibody, or a calcitonin gene-related peptide (CGRP) antibody. The wearable drug delivery device may include a needle and an insertion mechanism configured to insert the needle into a patient. A fluid pathway connector may define a sterile fluid flowpath between the container and the insertion mechanism. Optionally, a cannula initially disposed about the needle may be included. The cannula may be retained in the patient at an injection site created by the needle after the needle is withdrawn from the patient. Methods of assembly and operation are also provided.

Drug delivery device, method of manufacture, and method of use

Fill-finish assemblies facilitating the manufacture of a drug delivery device are disclosed. The fill-finish assembly may include a container, an insertion mechanism, a fluid pathway connection assembly disposed between the container and the insertion mechanism, and a carrier. The insertion mechanism may include a delivery member and an insertion mechanism housing. The insertion mechanism may be configured to move the delivery member from a retracted position inside the insertion mechanism housing to a deployed position outside the insertion mechanism housing. The fluid pathway connection assembly may be selectively activatable to establish fluid communication between the container and the delivery member. The carrier may have a hollow interior containing at least a portion of each of the container, the insertion mechanism, and the fluid pathway connection assembly. The carrier may be configured to hold the container, the insertion mechanism, and the fluid pathway connection assembly in alignment with each other.

Fill-finish assemblies and related methods

A device for dispensing biomaterial includes a handle configured to receive a syringe, the syringe including a biomaterial and a threaded plunger, and an engagement pin retained within the handle and slidable between a first position and a second position. The engagement pin is configured to engage the threaded plunger in the first position, the engagement pin is further configured to disengage from the threaded plunger in the second position.

Biomaterial dispensing device

A tissue removal device including customizable tips and method of use thereof. The tissue removal device may include an outer shaft having a removable tip attached to the outer shaft and a rotatable inner shaft extending through the outer shaft and having a rotatable cutting portion extending from the inner shaft. Disc material may be cut and removed from a surgical area using an auger-like and/or suction mechanism to facilitate the transfer of removed tissue away from the surgical area.

Surgical disc removal tool

Spinal plates with additional features to improve the stability of the interface between the plate and the underlying bone. A bone plate may include one or more sharp ridges along the periphery of its underside. When attached to bone, the ridge digs into the bone and increases stability. A bone plate may alternatively or additionally include one or more holes for optional spikes, which may be inserted once the plate is attached to the bone. By separating the spikes and including them as an optional component, the plate may enhance stability while reducing or eliminating the chance of the spike injuring the patient. Furthermore, bone screws may incorporate alternating notches and ridges into the head of the screw. The notches and ridges may interface with a set screw, thereby preventing rotation and loosening of the screw.

Spinal plate

A rotary sub-assembly for pumping of fluid is provided. The sub-assembly includes a hollow body defining a cavity having a longitudinal axis, the body comprising a cavity wall with at least two ports passing therethrough. At least a portion of the cavity has a non-circular cross-section such that a first constant or varying radial distance from the longitudinal axis to inwardly-offset segments of the cavity wall surrounding the two ports is less than a second constant or varying radial distance from the longitudinal axis to second segments of the cavity wall spaced apart from the two ports. A rotatable plunger is housed in the cavity. The plunger is sized and shaped such that a side wall of the plunger can establish a liquid-tight seal against the inwardly-offset segments of the cavity wall, but does not establish a liquid-tight seal with the second segments of the cavity wall spaced apart from the two ports.

Rotary plunger pump subsystems

A drive mechanism includes a housing, a piston adapted to impart movement to a plunger seal within a drug container, a plurality of biasing members disposed in parallel, and a retainer. The biasing members are disposed to release energy to cause movement of the piston from a retracted first position to the extended second position, the piston bearing against the plunger seal to dispense medicine. The retainer is disposed to maintain the biasing members in the energized position and to release the biasing members to permit the piston to dispense the medicine. The drive mechanism may also include an end-of-dose indicator to identify at least one of when the sleeve assembly is disposed subjacent a window in the housing, the relative motion of the sleeve assembly with reference to the window or another reference component, the stoppage of such motion, and the rated or change of rate of motion.

Drive mechanism for drug delivery pumps with integrated status indication

A fluid pathway assembly includes a needle insertion mechanism, a fluid conduit, and a fluid pathway connection. The fluid pathway assembly may further include a drug container to hold a drug fluid prior to initiation of the injection. The assembly may include a carrier disposed along at least a portion of the fluid pathway assembly, and/or a drug container. The fill-finish cartridge functions to retain the components of the fluid pathway assembly in a sterile condition, while allowing for easy integration of the fluid pathway assembly and the drug container into a standard fill-finish process. Methods of constructing a cartridge, filling a drug container included in a cartridge, and incorporating the same into a drug delivery device are disclosed.

Fill-finish cartridges for sterile fluid pathway assemblies and drug delivery devices incorporating fill-finish cartridges

A fluid pathway connection includes a piercing member, a connection hub, and a sliding pierceable seal, wherein the sliding pierceable seal is configured to move from a first position, where the piercing member is initially retained within a sterile cavity between the connection hub and the sliding pierceable seal, to a second position, where the pierceable seal has been penetrated by the piercing member. A filter may be utilized to enclose the sterile cavity from the outside environment. The fluid pathway connection may further be configured to move to a third position where one or more interconnects and/or one or more corresponding contacts are permitted to transmit a signal to the user. Such fluid pathway connections may be integrated into a drug container having a barrel and a plunger seal. A drug delivery pump includes such integrated fluid pathway connections and drug containers.

Integrated sliding seal fluid pathway connection and drug containers for drug delivery pumps

Drug delivery pump

A drive mechanism includes a housing, a piston adapted to impart movement to a plunger seal within a drug container, a plurality of biasing members disposed in parallel, and a retainer. The biasing members are disposed to release energy to cause movement of the piston from a retracted first position to the extended second position, the piston bearing against the plunger seal to dispense medicine. The retainer is disposed to maintain the biasing members in the energized position and to release the biasing members to permit the piston to dispense the medicine. The drive mechanism may also include an end-of-dose indicator to identify at least one of when the sleeve assembly is disposed subjacent a window in the housing the relative motion of the sleeve assembly with reference to the window or another reference component, the stoppage of such motion, and the rated or change of rate of motion.

Growing community of inventors

Royersford, PA, United States of America

Ryan Michael Agard