Gilead Sciences, Inc.

California Institute of Technology

Gilead Pharmasset LLC

Ryan McFadden

John O Link

James G Taylor

Richard L Mackman

William John Watkins

Michael Graupe

Hong Yang

Paul A Roethle

Lianhong Xu

Michael L Mitchell

Randall Halcomb

Kerim Babaoglu

Manoj C Desai

Hyung-Jung Pyun

Jeromy J Cottell

Chandrasekar Venkataramani

Aesop Cho

Scott E Lazerwith

Zheng-Yu Yang

Elizabeth M Bacon

Brian M Stoltz

Darryl Kato

Barton W Phillips

Scott D Schroeder

Winston C Tse

Hon Chung Hui

Hongtao Liu

Hongyan Guo

Gediminas J Brizgys

Richard Y Huang

Randall W Vivian

Jie Xu

Ana Zurisadai Gonzalez Buenrostro

Dmitry Koltun

Eda Y Canales

Rick Andrew Lee

Michael O'Neil Hanrahan Clarke

Jay P Parrish

Petr Jansa

Eric Q Parkhill

Haolun Jin

Samuel E Metobo

Adam James Schrier

Qi Liu

Michael R Mish

Michael Sangi

Xiaowu Chen

David Sperandio

Hai Yang

Gregory F Chin

Roland D Saito

Joshua J Van Veldhuizen

Mingzhe Ji

Evan S Krygowski

Paul Hrvatin

Yingmei Qi

Xiaochun Han

Zhenhong R Cai

Johannes H Voigt

Kyla Bjornson

Eric Lansdon

Salman Y Jabri

Yunfeng Eric Hu

Scott C Virgil

Daniel H Byun

Brandon Heath Brown

Jennifer Alissa Loyer-Drew

Chien-Hung Chou

Richard Hung Chiu Yu

Terry Kellar

James D Trenkle

Joseph H Saugier

Michael O' Neil Hanrahan Clarke

Manuel Munoz

Marina Shatskikh

Elizabeth Bacon

Laurent P Debien

Randall L Halcomb

Darin Allen

Jessica Jade Chao

Erwina Rudio

Jake Cha

Helene Kolding

Jennifer L Alleva

Joshua J Day

Tim Hansen

Timothy R Hansen

Amy Lee

James Taylor

Paul Roethle

Hongtae Liu

Thorstens A Kirschberg

Jianyu Sun

Neil Squires

Chuong U Kim

Xiaoning Sheng

The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

Inhibitors of peptidylarginine deiminases

The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.

HIV protease inhibitors

The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating cancers.

Imidazopyrimidine derivatives

Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

Modulators of toll-like receptors

Compounds disclosed herein including compounds of Formula I: and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection using compounds disclosed herein are also provided.

Therapeutic compounds

The invention provides compounds of formula I: or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula I.

The present invention provides methods of preparing 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one and related compounds.

Methods of preparing toll-like receptor modulators

The invention provides compounds and salts thereof as d herein. The invention also provides pharmaceutical compositions comprising a compound disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection, treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds disclosed herein.

2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS

Naphthalene acetic acid derivatives against HIV infection

The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula (I). 

Naphth-2-ylacetic acid derivatives to treat AIDS

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Foster City, CA, United States of America

Ryan McFadden