The United States of America, As Represented by the Secretary, Department of Health and Human Services

The University of Tokyo

New England Biolabs, Inc.

Ryan MacArthur

Hiroaki Suga

James Inglese

Clotilde K Carlow

Zhiru Li

Patricia Dranchak

Hao Yu

Disclosed herein are isolated peptides inhibit activity of a cofactor-independent phosphoglycerate mutase. In some examples, the isolated peptide is 6-20 amino acids long and includes the amino acid sequence of any one of SEQ ID NOs: 1-22 or 54, an analog or derivative thereof, or a pharmaceutically acceptable salt or ester thereof. In some examples, the peptide is a cyclic peptide with an N-terminal ring of 6-15 amino acids (for example, 6-10 amino acids) and a C-terminal linear portion of 1-9 amino acids (for example, 3-8 amino acids. Also disclosed h are methods of treating or inhibiting an infection in a subject, including administering to the subject an effective amount of a composition including one of more of the disclosed peptides, or analogs or derivative thereof, or pharmaceutically acceptable salts or esters thereof.

Peptide inhibitors of phosphoglycerate mutase and methods of use

Growing community of inventors

Odenton, MD, United States of America

Ryan MacArthur