The United States of America, as Represented by the Secretary, Department of Health and Human Services

Ryan M Greene

Victor C W Tsang

Patricia P Wilkins

Kathy Hancock

Compositions and methods for the detection ofand the diagnosis ofinfection are described. The nucleotide and amino acid sequences of the antigenicpolypeptides gp50, gp50and gp50are provided. The compositions contain synthetic antigenic polypeptides of larval origin prepared using the sequences described herein. Probes and primers for the detection or amplification ofnucleic acid molecules are also described. The polypeptides can be administered to a human or animal to protect againstinfection. In addition, the polypeptides are useful as research tools for studyingand as reagents in assays for the detection ofantibodies in a biological sample. The methods are sensitive and specific assays that utilize the stable recombinant or synthetic antigenic polypeptides or nucleic acid molecules encoding the larval polypeptides.

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Compositions and methods for the detection ofand the diagnosis ofinfection are described. The nucleotide and amino acid sequences of the antigenicpolypeptides gp50a, gp50b and gp50c are provided. The compositions contain synthetic antigenic polypeptides of larval origin prepared using the sequences described herein. Probes and primers for the detection or amplification ofnucleic acid molecules are also described. The polypeptides can be administered to a human or animal to protect againstinfection. In addition, the polypeptides are useful as research tools for studyingand as reagents in assays for the detection ofantibodies in a biological sample. The methods are sensitive and specific assays that utilize the stable recombinant or synthetic antigenic polypeptides or nucleic acid molecules encoding the larval polypeptides.

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San Antonio, TX, United States of America

Ryan M Greene