Manus Bio Inc.

Ryan Lim

Ajikumar Parayil Kumaran

Jason Eric Donald

Ryan Philippe

Liwei Li

Hsien-Chung Tseng

Swati Gupta

Krishna Patel

Christine Nicole S Santos

Christine Santos

The invention provides methods for making steviol glycosides, including RebM and glycosylation products that are minor products inleaves, and provides enzymes, encoding polynucleotides, and host cells for use in these methods. The invention provides engineered enzymes and engineered host cells for producing steviol glycosylation products, such as RebM, at high purity and/or yield. The invention further provides methods of making products containing steviol glycosides, such as RebM, including food products, beverages, oral care products, sweeteners, and flavoring products.

Uridine diphosphate-dependent glycosyltransferase circular permutants

The invention relates to methods and bacterial strains for making terpene and terpenoid products, the bacterial strains having improved carbon pull through the MEP pathway and to a downstream recombinant synthesis pathway.

Metabolic engineering for microbial production of terpenoid products

The invention provides methods for making steviol glycosides, including RebM and glycosylation products that are minor products in stevia leaves, and provides enzymes, encoding polynucleotides, and host cells for use in these methods. The invention provides engineered enzymes and engineered host cells for producing steviol glycosylation products, such as RebM, at high purity and/or yield. The invention further provides methods of making products containing steviol glycosides, such as RebM, including food products, beverages, oral care products, sweeteners, and flavoring products.

Microbial production of steviol glycosides

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Cambridge, MA, United States of America

Ryan Lim