University of California

New Atlas Biotechnologies LLC

Zestbio, Inc.

Ryan Joseph Protzko

John Eugene Dueber

Luke Latimer

A system and method for a metal sequestration composition comprising combining a galactaric salt or galactaric acid with a metalloid oxyanion, and an alkali compound. The system and method enable the production of a metal sequestration composition that either alone or in combination with other functional components (e.g. surfactants, solvents, pH modifiers) provide water treatment or cleaning compositions.

Galactarate based metal sequestration composition

The present disclosure provides methods of producing commodity products, the methods involving culturing a host cell that is genetically modified to produce a uronate dehydrogenase (UDH) that converts a sugar acid to its corresponding 1,5-aldonolactone, that uses NADPor NADas a cofactor, and that produces NADPH or NADH, respectively, where the host cell coexpresses an endogenous or a heterologous reductase that utilizes the produced NADPH or NADH to generate the commodity product or a precursor thereof. The present disclosure provides a method of producing downstream products of glycerol and pyruvate in a genetically modified microbial host cell, the method involving culturing a genetically modified microbial host cell of the present disclosure in a culture medium comprising D-galacturonic acid. The present disclosure provides variant UDH polypeptides that utilize NADP, nucleic acids encoding the variant UDH polypeptides; and host cells genetically modified with the nucleic acids.

Engineered microorganisms for production of commodity chemicals and cellular biomass

Disclosed herein are prokaryotic and eukaryotic microbes, includingand, genetically altered to biosynthesize tryptamine and tryptamine derivatives. The microbes of the disclosure may be engineered to contain plasmids and stable gene integrations containing sufficient genetic information for conversion of an anthranilate or an indole to a tryptamine. The fermentative production of substituted tryptamines in a whole-cell biocatalyst may be useful for cost effective production of these compounds for therapeutic use.

Growing community of inventors

Berkeley, CA, United States of America

Ryan Joseph Protzko