Chemocentryx, Inc.

Amgen Inc.

Ryan J Scamp

Penglie Zhang

Yibin Zeng

Pingchen Fan

Ju Yang

Christopher W Lange

Rebecca M Lui

Darren J McMurtrie

Darren J McMURTRIE

Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R, R, R, R, R, R, R, R, A, Z, Xand n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Heteroaryl-biphenyl amides for the treatment of PD-L1 diseases

Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.

Azetidinyl-acetamides as CXCR7 inhibitors

Heteroaryl-biphenyl amines for the treatment of PD-L1 diseases

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Fremont, CA, United States of America

Ryan J Scamp