Bristol-myers Squibb Compnay

Seattle Genetics, Inc.

Seagen Inc.

Ryan Heiser

Shyra Gardai

Neil Josephson

Benedetto Farsaci

Nicole Okeley

Anthony Cao

Jessica Field

Methods of producing T cells having reduced surface fucosylation and use thereof in adoptive cell therapy, in particular, in cancer treatment are provided.

T cells with reduced surface fucosylation and methods of making and using the same

This disclosure provides methods for treating a tumor in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD30 antibody. In some embodiments, the tumor is derived from a lymphoma (e.g., a Hodgkin lymphoma or a non-Hodgkin lymphoma). In certain embodiments, the anti-CD30 antibody is an antibody-drug conjugate, e.g., brentuximab vedotin.

Use of an anti-PD-1 antibody in combination with an anti-CD30 antibody in cancer treatment

Growing community of inventors

Lake Stevens, WA, United States of America

Ryan Heiser