Allergan Pharmaceuticals International Limited

Warner Chilcott Company, LLC

Allergan Therapeutics LLC

Ryan Gerald Loughlin

Brendan Muldoon

Gerarde Sweeney

Emma Karen Boyd

Stephen McCullagh

Roger Boissonneault

Stephen Mccullagh

A pharmaceutical soft gelatin capsule dosage form that includes (a) a shell that includes gelatin; and (b) a fill that includes at least one active ingredient, one or more polyethylene glycol, and a modified guar gum. The pharmaceutical soft gelatin capsule dosage form maintains its shell integrity (hardness) and fill viscosity after storage.

Pharmaceutical soft gelatin capsule dosage form with modified guar gum

A mesalamine pharmaceutical composition with reduced delivery variability for delivery of mesalamine to the colon that includes multiple dosage elements, and each dosage element includes mesalamine and an enteric coating. The enteric coating of each different dosage element differs so the release point of the mesalamine in the GI tract is varied. In one embodiment, a first dosage element releases about 30% to about 60% by weight of the total mesalamine in the composition after 60 minutes at a pH of about 6.6 in an aqueous phosphate buffer using a paddle apparatuswith a paddle speed of 100 rpm and a second dosage element releases about 40% to about 70% by weight of the total mesalamine after 60 minutes at a pH of about 7.2 in an aqueous phosphate buffer using a paddle apparatuswith a paddle speed of 100 rpm.

Mesalamine pharmaceutical composition with multiple dosage elements for reduced delivery variability

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Crumlin, Ireland

Ryan Gerald Loughlin