Cargill Inc.

University of Minnesota

Kadmon Corporation, LLC

Ryan Flynn

Kevin Ray Anderson

Frank P Lochel

Todd L Kurth

Bruce Robert Blazar

Christopher Patrick Stevermer

Alexandra Zanin-Zhorov

The invention relates to treatment of graft versus host disease (GVHD) using compounds that inhibit ROCK2. In preferred aspects, the present invention provides methods for the treatment of GVHD, including chronic GVHD (cGVHD) using compounds having the formulae 1-XXV, as set forth herein.

Treatment of GVHD

Polyglycerol compositions comprise no more than about 5% by weight of monoglycerol based on non-water ingredients of the polyglycerol composition, and have a combined tetraglycerol and higher polyglycerol content of at least about 55%. Methods of making such compositions from a crude glycerin comprising from 0.01 to 5 wt % of glycerol-containing compounds comprising acetate ester moieties are described.

Polyglycerol compositions

An aqueous binder composition is provided for use in the formation of fiber insulation and non-woven mats that comprises a reaction product of one or more Liquid Polyol Monomers; itaconic acid, its salts or anhydride; and a C4 to C6 polyol selected from the group consisting of pentaerythritol, trimethylol propane, neopentyl glycol, and mixtures thereof. The molar ratio of the combined alcohols (Liquid Polyol Monomers and C4 to C6 polyols) to itaconic acid is at least 2:1, wherein the molar ratio of Liquid Polyol Monomers to C4 to C6 polyols is from about 1:1 to about 30:1.

Aqueous binder comprising reaction products of itaconic acid

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Minneapolis, MN, United States of America

Ryan Flynn