Achaogen, Inc.

The Scripps Research Institute

Revagenix, Inc.

Ryan Cirz

Logan Andrews

Nathaniel E David

Floyd E Romesberg

Michael J Lopez

Frederick Cohen

Andrew Calabrese

Timothy Robert Kane

Nikolai Evdokimov

Kevin Michael Krause

Daniel John Cloutier

John Knox

Allison Seiko Komirenko

Ian Friedland

Adrian Jubb

Provided herein are aminoglycoside compounds, such as compounds of formula (I), (II), (III), (IV), (IVa), (V), (VI), (VIIa), or (VIIb) or pharmaceutically acceptable salts, solvates, stereoisomers, or tautomers of any of the foregoing, useful as therapeutic or prophylactic agents. Also provided herein are methods for their preparation. The compounds may be useful in treating a bacterial infection in a subject, for example a Gram-negative bacterial infection.

Aminoglycosides and uses thereof

Provided herein are methods of treating a bacterial infection, wherein the methods comprise administering (a) ceftibuten or a pharmaceutically acceptable salt thereof, or a hydrate of the foregoing; and (b) clavulanic acid, or a pharmaceutically acceptable salt thereof. Also provided are pharmaceutical compositions, articles of manufacture, and kits comprising a) ceftibuten or a pharmaceutically acceptable salt thereof, or a hydrate of the foregoing; and (b) clavulanic acid, or a pharmaceutically acceptable salt thereof, and uses thereof.

Combination products for the treatment of bacterial infections and methods of producing or dosing of same

The present invention provides methods and compositions for said inhibition of drug resistance. In one embodiment, said invention provides methods and compositions for said inhibition of antibiotic resistance. The invention generally involves said administration of achaogens, agents that inhibit said mutational process, to inhibit said evolution of drug resistance. Also, described herein are compositions that are suitable for use as achaogens.

Compositions and methods to reduce mutagenesis

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San Mateo, CA, United States of America

Ryan Cirz