Lanzatech, Inc.

Ryan Christopher Tappel

Michael Koepke

Sean Dennis Simpson

James Bruce Yarnton Haycock Behrendorff

Lars K Nielsen

Esteban Marcellin

Kaspar Valgepea

Jaeyoung Jung

Juniper Dee Gramling

Timothy James Politano

James MacAllister Clomburg

Renato De Souza Pinto Lemgruber

James Bruce Behrendorff

Renato De Lemgruber

Lars Nielsen

Microorganisms are genetically engineered to continuously co-produce amino acids, high-value, specialized proteins, microbial biomass, chemicals, or any combination thereof by microbial fermentation, particularly by microbial fermentation of a gaseous substrate. The microorganisms are C1-fixing. The production of ethylene, microbial biomass, and heterologous high-value, specialized proteins can be improved. This can be improved by varying promoters or nutrient limiting means.

Microorganisms and methods for the continuous co-production of high-value, specialized proteins and chemical products from C1-substrates

The invention provides microorganisms and methods for the production of polyhydroxybutyrate (PHB) from gaseous substrates. In particular, the invention provides a non-naturally occurring Wood-Ljungdahl microorganism comprising (a) an enzyme that converts acetyl-CoA to acetoacetyl-CoA, (b) an enzyme that converts acetoacetyl-CoA to 3-hydroxybutyryl-CoA, and (c) an enzyme that converts 3-hydroxybutyryl-CoA to polyhydroxybutyrate, and methods related thereto.

Wood-Ljungdahl microorganisms that produce polyhydroxybutyrate

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Skokie, IL, United States of America

Ryan Christopher Tappel