Lanzatech, Inc.

Ryan Christopher Tappel

Michael Koepke

Stephanie Rhianon Jones

Sean Dennis Simpson

James Bruce Yarnton Haycock Behrendorff

Lars K Nielsen

Esteban Marcellin

Kaspar Valgepea

Timothy James Politano

James MacAllister Clomburg

Juniper Dee Gramling

Jaeyoung Jung

Renato De Souza Pinto Lemgruber

Lars Nielsen

Microorganisms are genetically engineered to continuously co-produce amino acids, high-value, specialized proteins, microbial biomass, chemicals, or any combination thereof by microbial fermentation, particularly by microbial fermentation of a gaseous substrate. The microorganisms are C1-fixing. The production of ethylene, microbial biomass, and heterologous high-value, specialized proteins can be improved. This can be improved by varying promoters or nutrient limiting means.

Microorganisms and methods for the continuous co-production of high-value, specialized proteins and chemical products from C1-substrates

The invention provides microorganisms and methods for the production of polyhydroxybutyrate (PHB) from gaseous substrates. In particular, the invention provides a non-naturally occurring Wood-Ljungdahl microorganism comprising (a) an enzyme that converts acetyl-CoA to acetoacetyl-CoA, (b) an enzyme that converts acetoacetyl-CoA to 3-hydroxybutyryl-CoA, and (c) an enzyme that converts 3-hydroxybutyryl-CoA to polyhydroxybutyrate, and methods related thereto.

Wood-Ljungdahl microorganisms that produce polyhydroxybutyrate

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Skokie, IL, United States of America

Ryan Christopher Tappel