Amgen Inc.

Ryan Brown

Craig E Masse

Vinod Francis Patel

Brian K Albrecht

Matthew M Weiss

Stephen A Hitchcock

Holger Monenschein

Thomas T Nguyen

Patricia Lopez

Wenge Zhong

Qiufen May Xue

Yuan Cheng

Scott S Harried

Ted Charles Judd

Daniel La

Michael D Bartberger

James A Brown

Russell Graceffa

Lewis D Pennington

Thomas Nixey

Michael D Croghan

Bryant Yang

Charles Kreiman

Randall W Hungate

Stuart C Chaffee

Matthew R Kaller

Denise Lyn Andersen

Dean Hickman

Daniel B Horne

Dan Horne

Matthew K Kaller

James Brown

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, R, R, R, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

Beta-secretase modulators and methods of use

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, W, R, R, R, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

Beta-Secretase modulators and methods of use

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein R, W, B, R, R, R, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

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Belmont, MA, United States of America

Ryan Brown