Fujian Haixi Pharmaceuticals Co., Ltd

Ruyong Wang

Yan Feng

Xinshan Kang

Xuan Gong

Yizhang Ye

Fengsen Zhang

Zhonghong Wang

Xin Lian

Jianjia Zheng

Yueli Fu

Junqing Li

Provided herein are compounds of formula (I) having activity on a receptor protein tyrosine kinase, wherein R, R, R, A, Q, Z, X and W are set forth in the description, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof.

Heteroaryl compounds as kinase inhibitor

The present application provides a compound in formula III, and further provides a use of the compound in the synthesis of a Brivaracetam intermediate and a crude drug, and a synthesis method. A raw material involved in the method of the present application is low in costs and easily available; (R)-4-propyl-dihydrofuran-2-ketone having high optical purity can be prepared; complicated separation and purification steps are avoided; costs are reduced, and the method is more applicable to industrial production. 

Compound and use thereof in synthesis of brivaracetam intermediate and crude drug

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Fujian, China

Ruyong Wang