Xuanwu Hospital of Capital Medical University

Ruyi Zhang

Lin Li

Lan Zhang

Linlin Yin

Wen Jie Wang

Xi Chen

Lili Lin

Hongshun Gu

Cuicui Yang

The invention relates to flavanone derivatives, and preparation method and use thereof, particularly relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same, a preparation method thereof, and use thereof for preventing or treating a mental disorder or a nervous system disease. The compound of the invention exerts significant activity of inhibiting microglial activation and neuroinflammation, can antagonize dopamine D2 receptor, improve the ethological change in multiple animal models for mental disorders, effectively inhibit neuroinflammation and demyelination, and can be used to prevent or treat a mental disorder and a nervous system disease. 

Flavanone derivatives, and preparation method and use thereof

Composition containing iridoids such as morroniside and loganin, the use thereof in preparing medicaments for preventing and treating neurologic demyelinating diseases, and the method thereof in treating diseases related to neurologic demyelinating lesions are disclosed by the present application.

Composition containing iridoids and uses thereof

New use of icariin and Epimedium flavaoids containing icariin is provided by the present invention. Specifically, uses of compounds of Formula I or Epimedium containing compounds of formula I, Epimedium flavanoids, or extracts of Epimedium in manufacturing medicaments for treating, preventing, reducing and/or relieving diseases and/or conditoins related to neural myelin sheath impairments, or use of above materials in manufacturing medicaments for relieving demyelination and/or promoting repair of myelin sheath are provided by the present application, wherein, Ris selected from H, halogen, &#x2014;Calkyl, and &#x2014;C(O)&#x2014;Calkyl 

Use of icariin and epimedium flavonoids containing icariin to treat diseases associated with myelin sheath lesion

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Beijing, China

Ruyi Zhang