Jawaharlal Nehru Centre for Advanced Scientific Research

Ruthrotha Selvi Bharatha Vikru

Tapas Kumar Kundu

Mantelingu Kempegowda

Hari Kishore Annavarapu

Eswaramoorthy Muthusamy, Sr

Dinesh Jagadeesan

The present invention provides solution to the problem involved in delivery of active molecules to nucleus. More particularly, the invention provides intrinsically fluorescent and inherently surface functionalized carbon nanospheres which are non-toxic. Also, these carbon nanospheres [CSP] were adsorbed with CTPB [CSP-CTPB] and the adsorbed CSP-CTPB are permeable to cells with nuclear targeting ability. In addition, the present invention provides a composition, a process to prepare the composition comprising CSP with adsorbed active/therapeutic molecules. Further, the instant invention provides a method for delivering active molecules inside a cell nucleus.

Intrinsically fluorescent carbon nanospheres and a process thereof

The present invention relates to compounds of structural formula I as site-specific inhibitors of histone methyltransferase, where Rand Ris &#x2014;OCHor &#x2014;OH, Rand Ris &#x2014;OH or &#x2014;OAc; a process of isolating compound of structural formula Ia, where Rand Ris &#x2014;OCH, Rand Ris &#x2014;OH; a process of preparation of compound of structural formula Ib, where Rand Ris &#x2014;OCH, Rand Ris &#x2014;OAc; a process of preparation of compound of structural formula Ic, where Rand Ris &#x2014;OH, Rand Ris &#x2014;OH; and use of compounds of structural formula I for manufacture of a medicament for management of cancer and/or disease conditions in a subject in need thereof.

Site-specific inhibitors of histone methyltransferase (HMTASE) and process of preparation thereof

Site-specific inhibitors of histone methyltransferase [HMTase] and process of preparation thereof

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Karnataka, India

Ruthrotha Selvi Bharatha Vikru