University of Toronto

Consejo Superior De Investigaciones Cientificas

The University Court of the University of Aberdeen

Ruth Ross

Iain Robert Greig

Nadine Jagerovic

Chih-Chung Tseng

Paula Morales Lazaro

Lauren Whyte

Matteo Zanda

The present invention relates to a family of chromenopyrazole derivatives of formula (I): which have the ability to modulate the receptor of the cannabinoid family GPR55, whereby the invention also relates to the use of these compounds for the manufacture of a medicament for the treatment of diseases in which the GPR55 receptor has a physiological role such as diabetes, Parkinson's disease, multiple sclerosis, neuropathic pain, osteoporosis and cancers such as cholangiocarcinoma, breast cancer, ovarian and prostate cancer, glioblastoma, and cutaneous carcinoma.

Selective modulators of the activity of the GPR55 receptor: chromenopyrazole derivatives

The present disclosure relates to indole derivatives of the formula (I) which are cannabinoid type 1 receptor modulators and which are useful in the treatment of diseases in which modulation of the receptor is beneficial; to processes for their preparation; to pharmaceutical compositions comprising them; and to methods of using them. 

Cannabinoid type 1 receptor modulators

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Toronto, Canada

Ruth Ross