Hoechst Aktiengesellschaft

Aventis Pharma Deutschland, Gmbh

Ruth Raiss

Wilfried Schwab

Hans Jochen Lang

Werner Thorwart

Klaus U Weithmann

Christoph Naumann

Osamu Komiyama

Stefan M Ullner

Rolf Graeve

Yoshiko Terui

2-Cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives

-Cyano-,-dihydroxyhex-,-enecarboxamide derivatives

2-cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives

2-Cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of diseases or dissorders whose course involves increased connective tissue or cartilage degradation.

Phosphonoacetic acid derivatives and their use for treating degenerative joint disorders Compounds of the formula I ##STR1## are suitable for producing pharmaceuticals for the treatment and prophylaxis of degenerative joint disorders, of rheumatic disorders accompanied by cartilage breakdown, such as rheumatoid arthritis, joint trauma and chondrolysis as a consequence of prolonged immobilization of the joint, of inflammations, septic shock, disorders with impaired leukocyte adhesion, disorders caused by an elevated concentration of tumor necrosis factor alpha, such as cachexia or Crohn's disease.

Phosphonoacetic acid derivatives and their use for treating degenerative

Substituted aminoethane-1,1-bisphosphonic acids and aminoethane-1,1-alkylphosphinophosphonic acids, processes for their preparation and use thereof The invention relates to compounds of the formula I ##STR1## in which R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are a hydrogen atom or (C.sub.5 -C.sub.5)-alkyl, m is the integer 0 or 1, x is (C.sub.1 -C.sub.10)-alkyl, mono- or polysubstituted, a 5- or 6-membered ring having one nitrogen atom and optionally a further nitrogen or oxygen atom; aryl having 6 or 10 carbon atoms, which can be substituted; or cycloalkyl, to processes for the preparation of the compound of the formula I; to pharmaceuticals, and to their use for the treatment of osteoporosis and degenerative joint diseases.

N-cycloalkylaminoethane-1,1-bis (phosphonic acid) useful for the

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Frankfurt-am-Main, Germany

Ruth Raiss