Smithkline Beecham Corporation

Other

Johns Hopkins University

Ruth Judik Mayer

Jerry Leroy Adams

Ralph F Hall

James David Winkler

Lisa A Marshall

Floyd H Chilton

James S Dixon

Timothy Francis Gallagher

Derek R Buckle

Dennis Lee

Catherine E Ellis

Brian W Metcalf

Jeffrey Richard Jackson

David Glynn Smith

George L Seibel

Gary Christie

Ariane Elizabeth Marolewski

Raplh F Hall

The present invention is to the discovery of a novel CD23 processing enzyme which is of importance in the human immune response and regulation of IgE production, and is a protein expressed on the surface of a variety of cells.

CD23 processing enzyme preparation

Human KUZ polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human KUZ polypeptides and polynucleotides in the design of protocols for the treatment of inflammation, neural degeneration, allergic disorders, or other disorders involving a dis-regulation of the substrate cytokines or receptors, among others, and diagnostic assays for such conditions.

Human disintegrin metalloprotease KUZ gene

Anti-inflammatory compounds

This invention relates to the novel compounds and pharmaceutical compositions of Formula (I). This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound or composition of Formula (I).

This invention relates to the novel pharmaceutical compositions of Formulas (I) and (II) each of which comprises a compound of Formula (I) or (II) and a pharmaceutically acceptable diluent or carrier. This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound or composition of Formula (I) or (II).

New 14.alpha.-carboxyalkyl sterols are regulators of HMG-CoA reductase and inhibitors of mammalian 14.alpha.-methyl demethylase and are useful in lowering serum cholesterol levels and treating fungal infections.

Steroidal 14.alpha.-carboxy-alkyl derivatives as regulators of HMG-COA

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Wayne, PA, United States of America

Ruth Judik Mayer