Gruenenthal Gmbh

Grunenthal Gmbh

Gruenethal Gmbh

Ruth Jostock

Melanie Reich

Stefan Schunk

Sabine Hees

Stefan Oberboersch

Tieno Germann

Michael Engels

Klaus Schiene

Sven Kuehnert

Robert Frank

Achim Kless

Paul Ratcliffe

Thomas Koch

Klaus Linz

Beatrix Merla

Wolfgang Schroeder

Anita Wegert

Rene Michael Koenigs

Jean De Vry

Edward Bijsterveld

Thomas Christoph

Hans Schick

Michael Haurand

Helmut Sonnenschein

Ingo Konetzki

Bernd Sundermann

Gregor Bahrenberg

Hagen-Heinrich Hennies

Florian Jakob

Birgitta Henkel

Werner Guenter Englberger

Matthias Gerlach

Corinna Sundermann

Wolfgang Schröder

Sven Kühnert

Fritz Theil

Claudia Hinze

Michael Przewosny

Heinz Graubaum

Saskia Zemolka

Utz-Peter Jagusch

Michael Franz-Martin Engels

Christa Kneip

Dagmar Kaulartz

Thomas Tzschentke

Olga Groeger

Stefan Oberbörsch

René Michael Koenigs

Nikolay Sitnikov

Timo Struenker

Rene Kudick

Kamila Hennig

Ellen Klegraf

Timo Strünker

Wolfgang Schroder

Wolgang Schroder

Michael René KÖNIGS

Brigitta Henkel

The invention relates to 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives

The invention relates to 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives

The invention relates to 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives

The invention relates to 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

The invention relates to 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives

The invention relates to 1,3-diaza-spiro-[3.4]-octane derivatives, their preparation and use in medicine, particularly in various neurological disorders, including but not limited to pain, neurodegenerative disorders, neuroinflammatory disorders, neuropsychiatric disorders, substance abuse/dependence.

1,3-diaza-spiro-[3.4]-octane derivatives

The present invention relates to substituted spiro compounds, to processes for preparing them, to medicaments comprising these compounds and to the use of these compounds for producing medicaments.

Substituted spiro compounds and their use for producing pain-relief medicaments

Substituted benzamide compounds corresponding to formula (I) in which R5, R6, R7, R8, a, b, c, d, t, D and X have defined meanings, a process for their preparation, pharmaceutical compositions comprising such compounds, and a method of using such compounds to treat pain and other conditions mediated at least in part via the bradykinin 1 receptor.

Bradykinin 1 receptor modulating compounds

Substituted sulfonamide compounds with bradykinin receptor (B1R) modulating activity; processes for the preparation thereof, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or inhibit pain and/or other disorders and/or disease states.

Substituted sulfonamide compounds

Substituted sulfonamide compounds corresponding to the formula I processes for the preparation thereof, pharmaceutical compositions containing these compounds and the use of substituted sulfonamide compounds for the preparation of pharmaceutical compositions for treating pain and other conditions at least partly mediated via the bradykinin 1 receptor.

Substituted indole compounds corresponding to the formula I: In which R, R, R, R, R, R, R, A, D, T, q, s and t have defined meanings, processes for the preparation thereof, pharmaceutical compositions containing such compounds and the use of substituted indole compounds for the treatment or inhibition of pain and other conditions which are at least partly mediated by Bradykinin 1 receptors (B1R).

Substituted indole compounds

Substituted spiro-amide compounds corresponding to formula I in which R5 through R8, D, X, Y and Z have defined meanings, processes for preparing such spiro-amide compounds, pharmaceutical compositions containing such compounds, and methods of using such spiro-amide compounds for treating and/or inhibiting disorders or disease states mediated at least in part by the bradykinin 1 receptor.

Substituted spiro-amide compounds

Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment or inhibition of pain and/or various disorders or disease states.

Substituted spiroamide compounds corresponding to formula (I): wherein A, B, Q, Q, Q, Q, R, R, R, R, R, R, Rand Rhave defined meanings, processes for their preparation, pharmaceutical compositions containing such compounds, and the use of such compounds for treating or inhibiting pain or other conditions mediated at least in part by the bradykinin 1 receptor (B1R).

Spiro group-containing amide compounds having bradykinin 1 receptor (B1R) activity

Substituted sulfonamide compounds corresponding to formula I: processes for the preparation thereof, pharmaceutical compositions containing these compounds, and the use of such substituted sulfonamide compounds in pharmaceutical compositions for the treatment and/or inhibition of pain and other conditions at least partly mediated by the bradykinin 1 receptor.

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Stolberg, Germany

Ruth Jostock