Other

Nps Pharmaceuticals, Inc.

Myriad Pharmaceuticals, Inc.

Myrexis, Inc.

Myriad Genetics, Inc.

Manfredi, John

Ruth J Walton

Mark B Anderson

Warren S Weiner

Rachel M Slade

Yevgeniya Klimova

Kenton Zavitz

Robert J Halter

Jon Adam Willardsen

Ashantai J Yungai

Bradford C Van Wagenen

Scott T Moe

Thomas M Stormann

Daryl Lynn Smith

Robert M Barmore

Eric Delmar

Susan M Sheehan

Irina V Shcherbakova

John P Manfredi

Christine A Klein

Richard Trovato

Andrew Gassman

Yevgeniya I Klimova

Richard Travato

Leena Bhoite

Rachel Slade

The present disclosure relates to novel indole and tetrahydroindole core compounds useful for the treatment of disorders associated with a defect in vesicular transport (e.g., axonal transport).

Compounds for Alzheimer's disease

The invention provides novel compounds useful for the treatment of neurodegenerative disorders including Alzheimer's disease and dementia. The compounds have a substituents chosen from -L-C(&#x2550;O)OH, -L-CH&#x2550;CHC(&#x2550;O)OH, -L-C(&#x2550;O)NH, -L-C(&#x2550;O)NH(Calkyl), -L-C(&#x2550;O)N(Calkyl), -L-S(&#x2550;O)(Calkyl), -L-S(&#x2550;O)NH, -L-S(&#x2550;O)N(Calkyl), -L-S(&#x2550;O)NH(Calkyl), -L-C(&#x2550;O)NHOH, -L-C(&#x2550;O)CHNH, -L-C(&#x2550;O)CHOH, -L-C(&#x2550;O)CHSH, -L-C(&#x2550;O)NHCN, -L-NHC(&#x2550;O)OR, -L-C(&#x2550;O)NHR, -L-NH(C&#x2550;O)NHR, -L-C(&#x2550;O)N(R), -L-NH(C&#x2550;O)N(R), -L-sulfo, -L-(2,6 difluorophenol), -L-phosphono, and -L-tetrazolyl, where L is a linker.

Novel pyrrole derivatives are disclosed as A&#x3b2;-lowering agents for the treatment and prevention of neurodegenerative disorders characterized by the formation or accumulation of amyloid plaques comprising the A&#x3b2;peptide.

Pyrrole derivatives as therapeutic compounds

Compounds for alzheimer's disease

The present invention provides compounds, and pharmaceutical compositions containing those compounds, that are active at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases

Growing community of inventors

Bountiful, UT, United States of America

Ruth J Walton