Whitehead Institute for Biomedical Research

Ruth Foreman

Rudolf Jaenisch

Richard A Young

Alexander Marson

Alexander Meissner

G Grant Welstead

Yaqub Hanna

Brett Chevalier

Oliver Tobias Brambrink

Marius Wernig

Christopher J Lengner

Jacob Hanna

Rudolph Jaenisch

The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for generating or modulating (e.g., enhancing) generation of induced pluripotent stem cells by reprogramming somatic cells. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a pluripotent state and/or enhances the speed and/or efficiency of reprogramming. Certain of the compositions and methods relate to modulating the Wnt pathway.

Wnt pathway stimulation in reprogramming somatic cells with nuclear reprogramming factors

The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.

Reprogramming of somatic cells

WNT pathway stimulation in reprogramming somatic cells with nuclear reprogramming factors

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Somerville, MA, United States of America

Ruth Foreman