Merck + Co., Inc.

Corvas International, Inc.

University of Pennsylvania

Metabasis Therapeutics, Inc.

Bioreason, Inc.

Ruth F Nutt

Daniel F Veber

Stephen F Brady

William Charles Ripka

Robert J Ardecky

Matthew M Abelman

Joseph Edward Semple

Susan Yoshiko Tamura

Michael Rosenblatt

Ralph F Hirschmann

Odile Esther Levy

Terence Kevin Brunck

Michael Chorev

Marguerita S Lim-Wilby

Dong-Mei Feng

Eliahu Roubini

Mark E Duggan

Theresa M Williams

Yu Ge

Terry A Lyle

Robert J Gould

Thomas M Connolly

Todd Anthony Miller

Frederick W Holly

Stephen H Carpenter

Rolando A Spanevello

David C Rowley

Roger M Freidinger

Zacharia S Cheruvallath

Thomas R Webb

Jules A Shafer

Terrence M Ciccarone

Jing Wang

Sandor L Varga

Raymond Dagnino, Jr

William J Paleveda, Jr

John Eugene Reiner

Le T Duong

Hengyi Zhu

Robert G Strachan

Darryl Rideout

Michael P Caulfield

Harvey Schwam

Carl H Hoffman

S Dale Lewis

Christodoulos A Nicolaou

Richard Saperstein

Lynn H Caporale

Martin Hichens

Brian P Kelley

Colin J Loweth

Susan I Bassett

Roberta L McKee

Feiyue Wu

Shankari Mylvaganam

Jianzhong Sun

Mary A Napier

Richard L Vandlen

Jay J Levy

Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. In one embodiment, the compounds and compositions are thiazoles and thiadiazoles that inhibit the activity of protein tyrosine phosphatase 1B.

Thiazole and thiadiazole inhibitors of tyrosine phosphatases

A system for analyzing a vast amount of data representative of chemical structure and activity information and concisely providing conclusions about structure-to-activity relationships. A computer may adaptively learn new substructure descriptors based on its analysis of the input data. The computer may then apply each substructure descriptor as a filter to establish new groups of molecules that match the descriptor. From each new group of molecules, the computer may in turn generate one or more additional new groups of molecules. A result of the analysis in an exemplary arrangement is a tree structure that reflects pharmacophoric information and efficiently establishes through lineage what effect on activity various chemical substructures are likely to have. The tree structure can then be applied as a multi-domain classifier, to help a chemist classify test compounds into structural subclasses.

Method and system for artificial intelligence directed lead discovery through multi-domain clustering

The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.

3-amino-2-oxo-1-piperidnercetic derivatives as enzyme inhibitors

The present invention discloses peptide aldehydes which are potent inhibitors of factor Xa, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.

N-substituted glycine derivatives as enzyme inhibitors

Aromatic heterocyclic derivatives as enzyme inhibitors

Aromatic hetherocyclic derivatives as enzyme inhibitors

Relatively small cyclic peptides that mimic the biological and/or chemical activity of larger cyclic peptide such as somatostatin, as well as synthetic methods therefor. In certain embodiments, cyclic peptides of the invention have structure: ##STR1## wherein R.sub.NP1 is H, an amine protecting group, or a solid support and R.sub.NP2 is H or an amine protecting group.

Synthetic somatostatin mimics

The present invention discloses peptide aldehydes having a lactam group as part of the peptide backbone and having an original mimic group such as an amidinopiperidine or amidinophengyl tail. These compounds are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.

3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine

The present invention provides peptide aldehydes having an azetidinyl, prolyl or pipecolyl group as part of the peptide backbone and an arginine mimic group such as an amidinopiperidine or amidinophenyl tail. These compounds are potent and specific inhibitors of thrombin. Their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis are also described.

Arginine mimic derivatives as enzyme inhibitors

This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The compounds and their pharmaceutical compositions are useful for preventing thrombosis in mammals which are suspected of having a condition characterized by abnormal thrombosis.

Methionine sulfone and S-substituted cysteine sulfone derivatives as

This invention provides solution-phase and solid-phase methods for the synthesis of peptidyl argininals and to �novel! reagents useful therein.

Method of synthesis of peptidyl aldehydes

3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors

Growing community of inventors

San Diego, CA, United States of America

Ruth F Nutt