Bracco Research, USA

Human Genome Sciences, Inc.

Ruth E Wager

Craig A Rosen

Steven M Ruben

Kondareddiar Ramalingam

Adrian D Nunn

Karen E Linder

Michael F Tweedle

Natarajan Raju

Ramachandran S Ranganathan

Thangavel Arunachalam

Paul W Wedeking

Vivian R Albert

Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the &agr;, &ggr;, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.

Metal complexes derivatized with folate for use in diagnostic and therapeutic applications

Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the .alpha., .gamma., or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.

Metal complexes derivatized with folate for use in diagnostic and

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Rockville, MD, United States of America

Ruth E Wager