Vanderbilt University

Ruth Anne Gjierset

Paul R Reid

Joseph Parello

A method of treating cancer in a subject in need thereof, comprising administering to the subject a first amount of a compound of the HAT inhibitor of the following formula: wherein R is chosen from coenzyme A, (CH)NHCO(CH)NHCOR; (CH)NHCOR; (CH)NHCO(CH)NHCOR; Ris H, NH, NH, N, and Rcan optionally cyclize with at least one other Xto form a Cmembered ring containing C, O, S, or N; Ris chosen from alkyl, cycloalkyl, aryl, heteroaryl; Ris chosen from an alkyl, cycloalkyl, aryl, heteroaryl; Ris chosen from CH(OH)C(CH)CH)OCOR; Xis chosen from H or can cyclize with one other Xor Rto form a Cmembered ring containing C, O, S, or N; and Xis chosen from C, N, NH, and can optionally cyclize with at least one other Xor Rto form a Cmembered ring containing C, O, S, or N; or a pharmaceutically acceptable salt or hydrate thereof, thereby treating the cancer.

Methods of increasing the cytotoxicity of chemotherapeutic agents with multisubstrate inhibitors of histone, protein-Lys, polyamine acetylation, and polyamine metabolism

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San Diego, CA, United States of America

Ruth Anne Gjierset