Rg Biopharma LLC

Vanderbilt University

Sidney Kimmel Cancer Center

Ruth Anne Gjerset

Keya Bandyopadhyay

Joseph Parello

Casimir Blonski

Aimee Martin

Jean-Louis Baneres

Disclosed herein are methods and compositions for determining the sensitivity or enhancing the sensitivity of cells to the effects of topoisomerase I inhibitors. Also disclosed are methods and compositions for inducing cell death, apoptosis and/or growth arrest which may be used for tumor suppression.

Methods and compositions for topoisomerase I modulated tumor suppression

A method of treating cancer in a subject in need thereof, comprising administering to the subject a first amount of a compound of the HAT inhibitor of the following formula: wherein R is chosen from coenzyme A, (CH)NHCO(CH)NHCOR; (CH)NHCOR; (CH)NHCO(CH)NHCOR; Ris H, NH, NH, N, and Rcan optionally cyclize with at least one other Xto form a Cmembered ring containing C, O, S, or N; Ris chosen from alkyl, cycloalkyl, aryl, heteroaryl; Ris chosen from an alkyl, cycloalkyl, aryl, heteroaryl; Ris chosen from CH(OH)C(CH)CH)OCOR; Xis chosen from H or can cyclize with one other Xor Rto form a Cmembered ring containing C, O, S, or N; and Xis chosen from C, N, NH, and can optionally cyclize with at least one other Xor Rto form a Cmembered ring containing C, O, S, or N; or a pharmaceutically acceptable salt or hydrate thereof, thereby treating the cancer.

Methods of increasing the cytotoxicity of chemotherapeutic agents with multisubstrate inhibitors of histone, protein-lys, polyamine acetylation, and polyamine metabolism

The present invention details methods for the treatment of cancer. In particular it concerns the induction of apoptosis in cancer cells following treatment with inhibitors of DNA repair in combination with p53. Treatment of glioblastoma and breast tumor cells with inhibitors of DNA repair induced growth suppression that was a result of p53-mediated apoptosis. Thus it appears that inhibitors of DNA repair in combination with p53 is involved in restoration of p53-mediated apoptosis.

Down-regulation of DNA repair to enhance sensitivity to P53-mediated

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San Diego, CA, United States of America

Ruth Anne Gjerset