Braintree Laboratories, Inc.

Other

Russell W Pelham

Edmund V Dennett, Jr

Mark vB Cleveland

Mark Cleveland

Matthew Walker

Robert M Raleigh

Matthew Dean Walker

Bruce H Aronson

Shirrie Rosenthal

Robert M Raleigh, Jr

Mark V B Cleveland

Mark Vb Cleveland

Jack A Dipalma

Daniel Gat

Vivian Caballero

Disclosed herein are methods of administering compositions comprising a mixture of salts that induce purgation of the colon and are useful to cleanse the colon. Furthermore, the disclosed methods prevent degradation of PEG and allow for cleansing of the colon without the use of adjunct laxatives, including stimulant laxatives such as bisacodyl. The disclosed methods are superior to the prior art in that they allow for higher tolerability, improved safety, lower volumes, and improved patient compliance.

Methods of administering safe colon cleansing compositions

Disclosed herein are solid oral dosage formulations comprising sodium sulfate, magnesium sulfate, and potassium chloride for inducing purgation of the colon of a subject. Furthermore, the disclosed compositions and formulations are useful to cleanse the colon when administered in sufficient quantities. Methods for inducing purgation of the colon and for cleansing the colon are also disclosed.

Solid oral sulfate salt formulations for cleaning a colon and methods of using same

Solid oral sulfate salt formulations for cleansing a colon and methods of using same

Disclosed herein are formulations comprising lactitol for the treatment of chronic idiopathic constipation. As disclosed herein, the formulations are administered after or during a meal to improve the pharmacokinetics of the formulation. In particular, administration of the formulation after or during a meal decreases the absorption of lactitol and reduces the AUC.

Method of administering lactitol to reduce plasma concentration of lactitol

Stimulant laxative in combination with an osmotic laxative produces safe and effective bowel and colon cleansing with a reduced volume of liquid input. Administering to a patient an oral stimulant laxative, such as bisacodyl, followed, after a biologically determined interval, by a reduced volume of a PEG in water solution cleanses the bowels and colon in preparation for diagnostic colonoscopy, without the profuse uncontrollable diarrhea that typically follows either ingestion of large volume isotonic ravages, or smaller volume hypertonic lavages.

Method of bowel cleansing

Overnight relief of constipation symptoms is achieved, and control of bowel function is enhanced by oral administration of an effective or sufficient amount of a composition comprising polyethylene glycol (PEG), preferably dispersed and or dissolved in an aqueous medium. The PEG compositions used for the present invention are preferably substantially free of ancillary electrolytes.

Method of achieving overnight laxation and control of bowel function

Intestinal gas, cramping and/or anorectal irritation are treated by oral administration of an effective or sufficient amount of a composition comprising polyethylene glycol, preferably dispersed and/or dissolved in an aqueous medium. The PEG compositions used for the present invention are desirably substantially free of ancillary electrolytes.

Method of reducing intestinal gas, cramping and anorectal irritation

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Duxbury, MA, United States of America

Russell W Pelham