University of Georgia Research Foundation Inc

The United States of America, as Represented by the Secretary, Department of Health and Human Services

The University of Tennessee Research Foundation

Other

Russell W Carlson

Geert-Jan Boons

Conrad Padraig Quinn

Gary Stacey

Patricia P Wilkins

Therese Buskas

Alok Mehta

Elke Saile

Mahalakshmi Vasan

Margreet A Wolfert

Elmar Kannenberg

Herman Spaink

Anup K Datta

David S Stephens

Yih-Ling Tzeng

Biswa Choudhury

Christine Leoff

Jana Rauvolfova

Seshu K Gudlavalleti

The present invention presents the isolation, characterization and synthesis of oligosaccharides of. Also presented are antibodies that bind to such saccharide moieties and various methods of use for such saccharide moieties and antibodies.

Anthrax carbohydrates, synthesis and uses thereof

Provided are methods for recombinant production of an O-acetyltransferase and methods for acetylating capsular polysaccharides, especially those of a Serogroup Ausing the recombinant O-acetyltransferase, and immunogenic compositions comprising the acetylated capsular polysaccharide.

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Compositions for antagonizing gram negative bacterial endotoxic activity. Methods of antagonizing gram negative bacterial endotoxic activity. Methods of treating septic or toxic shock in a patient. Methods of treating or preventing a lipopolysaccharide mediated disorder in a patient. A method of extracting lipopolysaccharide from a gram negative bacteria by releasing lipopolysaccharide from a gram-negative bacteria, contacting the released lipopolysaccharide with polymixin B-agarose, and eluting the lipopolysaccharide from the polymixin B-agarose with an eluting solution comprising at least 1% deoxycholate to obtain thereby an lipopolysaccharide product.

LPS antagonists and methods of making and using the same

A purified lipid A from Rhizobium leguminosarum biovar phaseoli CE3, as well as analogs and derivatives of the purified lipid A are provided. Compositions containing heterogenous mixtures of lipid A from R. leguminosarum bv. phaseoli CE3 are also provided. The lipid A provided herein can be combined with a pharmaceutically acceptable carrier. Methods of stimulating the immune system in a subject, treating or preventing toxic shock in a subject, and methods of treating and preventing a lipopolysaccharide mediated disorder in a subject using the novel lipid A are provided.

Method for treating LPS-mediated disorders

A phytohormone for inducing root hair curling and root nodulation in the roots of leguminous plants particularly in the absence of nitrogen-fixing bacteria. The phytohormone comprises a pentasaccharide having a fatty acid condensed on the non-reducing end. A method for treating the roots of leguminous plants for inducing root hair curling and root nodulation is also disclosed.

Pentasaccharide phytohormones and methods for their use

A phytohormone for inducing root hair curling and root nodulation in the roots of leguminous plants particularly in the absence of nitrogen-fixing bacteria. The phytohormone comprises a pentassaccharide having a fatty acid condensed on the non-reducing end. a method for treating the roots of leguminous plants for inducing root hair curling and root nodulation is also disclosed.

Growing community of inventors

Athens, GA, United States of America

Russell W Carlson