Regeneration Technologies, Inc.

University of Florida Research Foundation, Incorporated

Russell S Donda

John F Wironen

Jamie M Grooms

C Randal Mills

Sean Hanstke

Mark Rogers Davidson

John R Bianchi

Gregg Ritter

Chris Seid

Rebecca Jaw

Thien Doan

Frank M Skidmore

Devices disclosed according to various embodiments use one or more arrays of atomic magnetometers to directly detection of relaxation of magnetic field induced subatomic precession within a target specimen. The disclosed devices and methods relate to application of utilization of a magnetic sensor with unique properties requiring changes in design, allowing new functions, and requiring alternative analysis methodologies. Various embodiments are also directed to methods for obtaining and processing magnetic signals. These methods may take advantage of the unique spatial arrangement of the atomic magnetometers and the capacity sensors to be used in either a scalar or a vector mode. Various embodiments have advantages over current techniques utilized for imaging of anatomical and non-anatomical structures. Such advantages may include, for example: development of a wearable, portable array, lower power consumption, potential wafer-level fabrication, the potential for development of a more rapid signal, decreased need for development of strong magnetic fields, and lower cost allowing wider availability.

Atomic magnetometer sensor array magnetic resonance imaging systems and methods

Disclosed herein are novel injectable, biocompatible compositions, preferably, comprising a combination of particulate, processed tissue and a carrier. Specifically disclosed are compositions comprising acellular, pulverized dermis combined with at least one glycosaminoglycan and/or gelatin. The subject compositions provide for improved retention of the composition at the site of implantation. Also disclosed are medical applications using the disclosed compositions, such as cosmetic enhancement or filling in of voids due to abnormalities, injuries, surgery, or aging. In addition, kits comprising at least one container of a freeze-dried, particulate tissue and at least one container of a glycosaminoglycan, or crude platelet extract and used thereof as a wound treatment/dressing, are disclosed.

Processed soft tissue for topical or internal application

This invention includes a novel method for safely, effectively and efficiently pooling of tissues for treatment prior to implantation into a recipient in need thereof. In one embodiment, the method includes perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation. Target decontamination goals for this process include between about a one (1) to twelve (12) log reduction in bacterial contamination, between about a one (1) to fifteen (15) log reduction in enveloped virus contamination, up to about a five (5) log reduction in non-enveloped virus contamination, between about a two (2) to ten (10) fold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.

Implant sterilization apparatus

Tissue pooling process

This invention relates to implants useful as stents for opening or strengthening biological conduits, or as grafts or conduits for replacing or connecting portions of biological tissues having a lumen. Accordingly, the implants of this invention may be applied in portions of the peripheral and coronary vascular system, biliary, urinary, esophageal, digestive, ocular, tracheal, bronchial, reproductive, and neural systems. The implant comprises a segment of bone having a lumen through at least a part thereof, and wherein at least a portion of the implant is demineralized so as to be pliable.

Luminal graft, stent or conduit made of cortical bone

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Gainesville, FL, United States of America

Russell S Donda