Cygnus, Inc.

Animas Technologies, LLC

Pfizer Corporation

Animas Corporation

Other

Bioelectric Devices, Inc.

Cyngnus, Inc.

Russell O Potts

Michael J Tierney

Janet A Tamada

Matthew J Lesho

Bret Berner

Timothy Christian Dunn

Ronald T Kurnik

Charles W Wei

Michael D Garrison

Chia-Ming Chiang

Janan Jona

Norman A Parris

Steven Waterhouse

Russell Ford

Yalia Jayalakshmi

Michael L Francoeur

Lynn Kim

Jonathan J Oliver

Kathleen C Farinas

Michel Martin Maharbiz

Pravin L Soni

Thomas E Conn

Christopher Uhegbu

Shashi P Desai

Jonathan James Oliver

Michael Motion

Thomas Arnold Peyser

Herbert L Berman

James W Moyer

Mikhail A Kouchnir

An intelligent bioelectric module for use with a drug delivery system has a case and a set of at least two electrodes in electrical communication with a detection surface of the case. The case is configured so that, in use, the detection surface comes into electrical communication with (i) a second surface of the delivery system when a first surface of the delivery system has been put into contact with a tissue surface of a human or animal subject or (ii) the tissue surface that is adjacent to a portion contacted by the first surface of the delivery system or (iii) both the second surface and the tissue surface.

Intelligent bioelectric module for use with drug delivery system

The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.

Method and device for predicting physiological values

Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.

Monitoring of physiological analytes

Described are devices, methods, and kits for non-invasively measuring glucose. In general, the devices comprise skin patches for placement on a skin surface and measurement devices for measuring glucose collected in the patches. The patches may include an adhesive material, a collection layer, an interface layer, and a sweat-permeable membrane. The sweat-permeable membrane is configured to act as a barrier to epidermal contaminants and glucose brought to the skin surface via diffusion. In this way, non-correlatable skin surface glucose will not be measured. The patches may further include components to induce a local sweat response. The measurement device typically includes a display, a processor, and a measurement mechanism. The methods typically include the steps of wiping the skin surface with a wipe containing at least one solvent for removing glucose, placing a patch on a skin surface, and measuring glucose collected in the patch. Kits comprising the patch and measurement device are also described.

Devices, methods, and kits for non-invasive glucose measurement

The present invention relates to methods to increase the number of analyte-related signals used to provide analyte measurement values, e.g., when two or more analyte-related signals are used to obtain a single analyte measurement value a 'rolling' value based on the two or more signals can be employed. In another aspect, interpolation and/or extrapolation methods are used to estimate unusable, missing or error-associated analyte-related signals. Further, interpolation and extrapolation of values are employed in another aspect of the invention that reduces the incident of failed calibrations. Further, the invention relates to methods, which employ gradients and/or predictive algorithms, to provide an alert related to analyte values exceeding predetermined thresholds. The invention includes the above-described methods, one or more microprocessors programmed to execute the methods, one or more microprocessors programmed to execute the methods and control at least one sensing and/or sampling device, and monitoring systems employing the methods described herein.

Methods for estimating analyte-related signals, microprocessors comprising programming to control performance of the methods, and analyte monitoring devices employing the methods

The present invention relates to a predictive-kinetic method for use with data processing of a sensor-generated signal, as well as, microprocessors and monitoring systems employing such a predictive-kinetic method. Data from a transient region of a signal is used with suitable models and curve-fitting methods to predict the signal that would be measured for the system at the completion of the reaction. The values resulting from data processing of sensor response using the methods of the present invention are less sensitive to measurement variables.

Methods for measuring analyte in a subject and/or compensating for incomplete reaction involving detection of the analyte

A method is provided for continually or continuously measuring the concentration of target chemical analytes present in a biological system, and processing analyte-specific signals to obtain a measurement value that is closely correlated with the concentration of the target chemical analyte in the biological system. One important application of the invention involves a method for signal processing in a system for monitoring blood glucose values.

Signal processing for measurement of physiological analytes

Monitoring a physiological analytes

Devices and methods are provided for frequently measuring the concentration of an analyte present in a biological system. A monitoring system having at least two components is employed in order to allow separation of data collection from data processing and display. Such separation allows greater flexibility and convenience for the user.

Devices and methods for frequent measurement of an analyte present in a biological system

The present invention relates to methods of formulating analyte data databases, the databases themselves, and methods of manipulating the same. In one aspect the present invention includes the formulation of analyte data points, derived data, and data attributes databases comprising data points collected using an analyte monitoring device capable of frequent monitoring of analyte concentrations or amounts. Such data points may comprise acquired data (e.g., values corresponding to analyte concentrations or amounts as measured by said analyte monitoring device). These data points are then associated with one or more relevant data attributes. The resulting databases may be manipulated to determine relationships among the components of the database.

Formulation and manipulation of databases of analyte and associated values

Methods for computing rolling analyte measurement values, microprocessors comprising programming to control performance of the methods, and analyte monitoring devices employing the methods

An automated system for continual transdermal extraction of analytes present in a biological system is provided. The system can be used for detecting and/or measuring the concentration of the analyte using an electrochemical biosensor detection means. The system optionally uses reverse iontophoresis to carry out the continual transdermal extraction of the analytes.

Biosensor and methods of use thereof

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San Francisco, CA, United States of America

Russell O Potts