Genevant Sciences Gmbh

Phaserx, Inc.

Russell N Johnson

Mary Gallagher Prieve

Charbel Diab

Pierrot Harvie

Sean D Monahan

Maher Qabar

Anna Galperin

Michael S DeClue

Debashish Roy

Amber E Paschal

Michael E Houston, Jr

Michael S Declue

Mary G Prieve

Michael E Houston

Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.

Block copolymers

Nucleic acid constructs and methods of using the same

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Seattle, WA, United States of America

Russell N Johnson