Resolution Sciences Corporation

Advanced Pathology Ststems, Inc.

Russell L Kerschmann

Mark Reddington

Andrew D Hendrickson

Thomas Kuwahara

Michael E Bolles

Benn P Herrera

Ronald Odom

Andrew Hendrickson

A method for en bloc staining a biological sample by (a) immersing the sample in a staining solution including an ionically conductive solution and a charged stain molecule or stain precursor that associates with a component of the sample; and (b) applying an electric field across the staining solution, whereby the stain molecule penetrates into the sample. Staining times are reduced.

Electrophoresis-assisted staining of materials

A method for preparing an organic sample for cutting and subsequent examination, involving immersing the sample in a composition containing: an infiltrating substance; an embedding substance, which can be the same or different from the infiltrating substance; and a stain that chemically associates with the organic sample, wherein the stain exhibits different detectable properties when associated and not associated with the sample.

Combined en bloc staining and embedding process

A method and apparatus for monitoring and evaluating the performance and condition of histology laboratory microtomes and microtome accessories including knives, motor drives, and illumination devices. Irregularities in an image of the surface of a block mounted on the microtome are detected and characterized, the block having been subjected to mechanical sectioning by the microtome to produce a cut block face. The image of light reflected from the surface of the block, either specular or non-specular, is recorded and subjected to graphical analysis to extract, quantify, and interpret patterned features, including those indicating anomalies in the function of the microtome, its accessories, or the tissue block itself.

Method and apparatus for measurement of microtome performance

In general, the invention consists of a means for staining a sample with a fluorescent dye, a means for producing a darkfield image of the fluorescent stained sample, and a means of transforming an image of a sample stained with one or more darkfield dyes into an image stained with one or more brightfield dyes for examination on a computer monitor. The process includes applying a digital lookup table or other computational means in order to convert the darkfield data to brightfield forms, and a means of displaying said transformed information. Preferably, the imaging means is a block face microscope, and the means for transforming the images is a digital computer.

Growing community of inventors

Mill Valley, CA, United States of America

Russell L Kerschmann