E.i. Dupont De Nemours and Company

The Dupont Merck Pharmaceutical Company

Du Pont Merck Pharmaceutical

Russell H Neubauer

Neil R Ackerman

Scott E Loveless

Bruce D Jaffee

Richard R Harris

Lee Terry Bacheler

Stephen R Petteway

Blair Q Ferguson

4-Quinolinecarboxylic acids and derivatives thereof, such as 2-(2'-fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methyl-4-quinolinecarboxylic acid, are useful as immunodulatory and anti-inflammatory agents. Pharmaceutical formulations containing such compounds are useful for the treatment of autoimmune diseases, organ transplantation rejection, graft vs. host disease, multiple sclerosis, and chronic inflammatory diseases such as rheumatoid arthritis.

4-quinoline carboxylic acid derivatives useful as immunosuppressive

The invention relates to stable mammalian cells lines having integrated in their genome two heterologous DNA sequences, a first DNA sequence which expresses a trans-acting regulatory protein, and a second DNA sequence which expresses a desired protein, said second DNA sequence being linked to a target DNA regulatory control sequence which is responsive to the expressed trans-acting regulatory protein.

Stable human cell lines expressing an indicator gene product under

4-Quinolinecarboxylic acids and derivatives thereof, such as 2-(2'-fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methyl-4-quinolinecarboxylic acid, are useful as immunomodulatory and anti-inflammatory agents. Pharmaceutical formulations containing such compounds are useful for the treatment of autoimmune diseases, organ transplantation rejection, graft vs. host disease, multiple sclerosis, and chronic inflammatory diseases such as rheumatoid arthritis.

4-Quinoline carboxylic acid derivatives useful as immunosuppressive

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West Chester, PA, United States of America

Russell H Neubauer